ArticleIndian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India2013
Tadalafil significantly reduces ischemia reperfusion injury in skin island flaps.
Article in Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- The effect of chrysin on ischemia-reperfusion injury in the rat epigastric artery skin island flap.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Use of Phosphodiesterase Inhibitors in the Postoperative Period of Skin Flaps: A Systematic Review.Plastic and reconstructive surgery. Global open · 2023Article
- Effects of sildenafil and tadalafil on skin flap viability.Archives of dermatological research · 2022Article
- Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury.The Indian journal of medical research · 2017Article
- Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with "F-5" Gene.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Bilirubin provides perforator flap protection from ischaemia-reperfusion injury in a rat model: a preliminary result.International wound journal · 2016Article
- The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia/reperfusion injury.The Kaohsiung journal of medical sciences · 2016Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNumerous pharmacological agents have been used to enhance the viability of flaps. Ischemia reperfusion (I/R) injury is an unwanted, sometimes devastating complication in reconstructive microsurgery. Tadalafil, a specific inhibitor of phosphodiesterase type 5 is mainly used for erectile dysfunction, and acts on vascular smooth muscles, platelets and leukocytes. Herein, the protective and therapeutical effect of tadalafil in I/R injury in rat skin flap model is evaluated. MATERIALS AND
methodsSixty epigastric island flaps were used to create I/R model in 60 Wistar rats (non-ischemic group, ischemic group, medication group). Biochemical markers including total nitrite, malondialdehyde (MDA) and myeloperoxidase (MPO) were analysed. Necrosis rates were calculated and histopathologic evaluation was carried out.
resultsMDA, MPO and total nitrite values were found elevated in the ischemic group, however there was an evident drop in the medication group. Histological results revealed that early inflammatory findings (oedema, neutrophil infiltration, necrosis rate) were observed lower with tadalafil administration. Moreover, statistical significance (P < 0.05) was recorded.
conclusionsWe conclude that tadalafil has beneficial effects on epigastric island flaps against I/R injury.
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