ArticleIndian journal of orthopaedics2013
Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density.
Article in Indian journal of orthopaedics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Effects of vitamin D and calcium supplementation on bone mineral density among Thai youth using daily HIV pre-exposure prophylaxis.Journal of the International AIDS Society · 2020Trial
- The Extensive Study of Magnesium Deficiency, 25-(OH) Vitamin D3, Inflammatory Markers, and Parathyroid Hormone in Relation to Bone Mineral Density in Iraqi Osteoporosis Patients: A Cross-Sectional Study.Health science reports · 2025Article
- Physiology of Vitamin D-Focusing on Disease Prevention.Nutrients · 2024Review
- The relationship between vitamin D and adolescents' parathyroid hormone and bone mineral density.Przeglad menopauzalny = Menopause review · 2024Article
- The Role of Herbal Medicine in Modulating Bone Homeostasis.Current topics in medicinal chemistry · 2024Review
- Agreement of Parathyroid Hormone Status Measured by Intact and Biointact Parathyroid Hormone Assays among Chronic Kidney Disease Patients and Its Correlation with Bone Turnover Parameters.The Malaysian journal of medical sciences : MJMS · 2023Article
- Bone parameters of elite athletes with oligomenorrhea and prevalence seeking medical attention: a cross-sectional study.Journal of bone and mineral metabolism · 2021Article
- The association between serum vitamin D and body composition in South African HIV-infected women.Southern African journal of HIV medicine · 2021Article
- Mechanism and adverse effects of COVID-19 drugs: a basic review.International journal of physiology, pathophysiology and pharmacology · 2021Review
- Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Article
- Suppression of Parathyroid Hormone as a Proxy for Optimal Vitamin D Status: Further Analysis of Two Parallel Studies in Opposite Latitudes.Nutrients · 2020Article
- The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents.Nutrients · 2020Article
- Article
- Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study.Osteoporosis and sarcopenia · 2018Article
- Vitamin D Intake among Premenopausal Women Living in Jeddah: Food Sources and Relationship to Demographic Factors and Bone Health.Journal of nutrition and metabolism · 2018Article
- Serum 25-hydroxyvitamin D and bone turnover markers in Palestinian postmenopausal osteoporosis and normal women.Archives of osteoporosis · 2017Article
- The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population.Open access Macedonian journal of medical sciences · 2017Article
- The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study.Journal of bone and mineral metabolism · 2016Article
- A Cross-Sectional Study of Postpartum Changes in Bone Status in Indian Mothers.Journal of obstetrics and gynaecology of India · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone mineral densiy (BMD) is known to be affected by serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels. Indian data pertinent to above observation is scant. Our study aimed to investigate the relationships between serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels and bone mineral density (BMD) in a cohort of Indian patients. MATERIALS AND
methodsAdults with or without fragility fractures with low BMD at the hip or lumbar spine were evaluated clinically along with laboratory investigations. T-scores of the hip and spine were derived from BMD-DEXA (dual-energy X-ray absorptiometry). Multivariate regression models were used to investigate the relationships between serum 25(OH) D, iPTH and BMD.
resultsTotal of 102 patients (male:female = 38:64) with a mean age of 62.5 ± 6.4 years were included in the study. Forty-four patients had osteopenia. Osteoporosis was present in 58 patients. The mean values for serum 25(OH) D and iPTH levels were 21.3 ± 0.5 ng/ml and 53.1 ± 22.3 pg/ml, respectively. In 84.3% of patients, serum 25(OH) D levels were below 30 ng/ml (Normal = 30-74 ng/ml), confirming vitamin D deficiency. There was no association between 25(OH) D levels and BMD at the hip or lumbar spine (P = 0.473 and 0.353, respectively). Both at the hip and lumbar spine; iPTH levels, male gender, body mass index (BMI) and age were found to be significant predictors of BMD. Patients with higher BMI had significantly lower BMD and T-score. At levels <30 ng/ml, 25(OH) D was negatively associated with iPTH (P = 0.041).
conclusionAmong our cohort of patients with low BMD, no direct relationship between serum 25(OH) D levels and BMD was observed. However, a negative correlation between iPTH and 25(OH) D at serum 25(OH) D concentrations <30 ng/ml. Serum iPTH levels showed a significant negative association with BMD at the hip and lumbar spine. Our findings underscore the critical role of parathyroid hormone in bone metabolism and health.
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