ArticleCerebral cortex (New York, N.Y. : 1991)2015
Systematic, cross-cortex variation in neuron numbers in rodents and primates.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 143 citations in OpenAlex.
- Hierarchical Flows of Human Cortical Activity.bioRxiv : the preprint server for biology · 2026Article
- Layer-specific cellular composition of mouse primary somatosensory and human temporal cortex: a direct 3D confocal counting approach.Frontiers in neuroanatomy · 2026Article
- Geometric influences on the regional organization of the mammalian brain.bioRxiv : the preprint server for biology · 2025Article
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.Nature methods · 2024Article
- Abnormal structural‒functional coupling patterning in progressive supranuclear palsy is associated with diverse gradients and histological features.Communications biology · 2024Article
- Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons.Cell reports · 2024Article
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- The flattening of spacetime hierarchy of theNational science review · 2024Article
- Molecular signatures of cortical expansion in the human fetal brain.bioRxiv : the preprint server for biology · 2024Article
- Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity.PLoS biology · 2023Article
- Ubiquitous lognormal distribution of neuron densities in mammalian cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023Review
- Evolutionary shaping of human brain dynamics.eLife · 2022Article
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions.International journal of molecular sciences · 2021Review
- Creative Destruction: A Basic Computational Model of Cortical Layer Formation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Optimization of whole-brain rabies virus tracing technology for small cell populations.Scientific reports · 2021Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Uniformity, local variability, and systematic variation in neuron numbers per unit of cortical surface area across species and cortical areas have been claimed to characterize the isocortex. Resolving these claims has been difficult, because species, techniques, and cortical areas vary across studies. We present a stereological assessment of neuron numbers in layers II-IV and V-VI per unit of cortical surface area across the isocortex in rodents (hamster, Mesocricetus auratus; agouti, Dasyprocta azarae; paca, Cuniculus paca) and primates (owl monkey, Aotus trivigratus; tamarin, Saguinus midas; capuchin, Cebus apella); these chosen to vary systematically in cortical size. The contributions of species, cortical areas, and techniques (stereology, "isotropic fractionator") to neuron estimates were assessed. Neurons per unit of cortical surface area increase across the rostro-caudal (RC) axis in primates (varying by a factor of 1.64-2.13 across the rostral and caudal poles) but less in rodents (varying by a factor of 1.15-1.54). Layer II-IV neurons account for most of this variation. When integrated into the context of species variation, and this RC gradient in neuron numbers, conflicts between studies can be accounted for. The RC variation in isocortical neurons in adulthood mirrors the gradients in neurogenesis duration in development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.