ArticleCerebral cortex (New York, N.Y. : 1991)2015
Differential modifications of synaptic weights during odor rule learning: dynamics of interaction between the piriform cortex with lower and higher brain areas.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Biophysical mechanisms underlying the generation and maintenance of rule-learning engram.Communications biology · 2026Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Representational drift and learning-induced stabilization in the piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circuit dynamics of the olfactory pathway during olfactory learning.Frontiers in neural circuits · 2024Review
- Learning-dependent structural plasticity of intracortical and sensory connections to functional domains of the olfactory tubercle.Frontiers in neuroscience · 2023Article
- Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning.Nature communications · 2022Article
- Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- TNF-α Orchestrates Experience-Dependent Plasticity of Excitatory and Inhibitory Synapses in the Anterior Piriform Cortex.Frontiers in neuroscience · 2022Article
- Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat.Scientific reports · 2021Article
- Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex.eLife · 2021Article
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A specific olfactory cortico-thalamic pathway contributing to sampling performance during odor reversal learning.Brain structure & function · 2019Article
- The Value of Homework: Exposure to Odors in the Home Cage Enhances Odor-Discrimination Learning in Mice.Chemical senses · 2019Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation.Scientific reports · 2017Article
- Insulin Modulates Neural Activity of Pyramidal Neurons in the Anterior Piriform Cortex.Frontiers in cellular neuroscience · 2017Article
- Gamma and Beta Oscillations Define a Sequence of Neurocognitive Modes Present in Odor Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Dynamic cortical lateralization during olfactory discrimination learning.The Journal of physiology · 2015Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Learning of a complex olfactory discrimination (OD) task results in acquisition of rule learning after prolonged training. Previously, we demonstrated enhanced synaptic connectivity between the piriform cortex (PC) and its ascending and descending inputs from the olfactory bulb (OB) and orbitofrontal cortex (OFC) following OD rule learning. Here, using recordings of evoked field postsynaptic potentials in behaving animals, we examined the dynamics by which these synaptic pathways are modified during rule acquisition. We show profound differences in synaptic connectivity modulation between the 2 input sources. During rule acquisition, the ascending synaptic connectivity from the OB to the anterior and posterior PC is simultaneously enhanced. Furthermore, post-training stimulation of the OB enhanced learning rate dramatically. In sharp contrast, the synaptic input in the descending pathway from the OFC was significantly reduced until training completion. Once rule learning was established, the strength of synaptic connectivity in the 2 pathways resumed its pretraining values. We suggest that acquisition of olfactory rule learning requires a transient enhancement of ascending inputs to the PC, synchronized with a parallel decrease in the descending inputs. This combined short-lived modulation enables the PC network to reorganize in a manner that enables it to first acquire and then maintain the rule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.