ArticleReproduction (Cambridge, England)2013
Plasticity of basal cells during postnatal development in the rat epididymis.
Article in Reproduction (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Postnatal Cell Type- and Segment-Specific Localization of EGFR and Its Ligands (EGF, TGF-α, and AREG) in the Rat Epididymis.Anatomia, histologia, embryologia · 2026Article
- Basal and Immune Cells of the Epididymis: An Electron Microscopy View of Their Association.Advances in experimental medicine and biology · 2025Review
- Molecular Pathways Implicated in the Differentiation and Function of Epididymal Basal Cells.Advances in experimental medicine and biology · 2025Review
- Advancement and Potential Applications of Epididymal Organoids.Biomolecules · 2024Review
- Epithelial and mesenchymal fate decisions in Wolffian duct development.Trends in endocrinology and metabolism: TEM · 2023Review
- Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice.Frontiers in endocrinology · 2022Article
- Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein.Histochemistry and cell biology · 2021Article
- Self-renewal and differentiation of rat epididymal basal cells using a novel in vitro organoid model†.Biology of reproduction · 2021Article
- Article
- Development and Differentiation of Epididymal Epithelial Cells in Korean Native Black Goat.Animals : an open access journal from MDPI · 2020Article
- Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats.Tissue barriers · 2020Article
- The expression and localization of V-ATPase and cytokeratin 5 during postnatal development of the pig epididymis.Asian-Australasian journal of animal sciences · 2020Article
- Androgens are essential for epithelial cell recovery after efferent duct ligation in the initial segment of the mouse epididymis†.Biology of reproduction · 2020Article
- Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa.Andrology · 2019Review
- Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.Scientific reports · 2018Article
- The expression patterns of aquaporin 9, vacuolar HHistochemistry and cell biology · 2017Article
- Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.Nature communications · 2016Article
- Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.PloS one · 2016Article
- Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem Cells.Biology of reproduction · 2015Article
- Role of testicular luminal factors on Basal cell elongation and proliferation in the mouse epididymis.Biology of reproduction · 2015Article
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4 authors.
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Abstract
Our previous study has shown that basal cells sense luminal factors by forming a narrow body projection that can cross epithelial tight junctions. As a first step toward characterizing the structural plasticity of basal cells, in this study, we followed their appearance and morphology in the rat epididymis and vas deferens (VD) during postnatal development and examined their modulation by androgens in adulthood. Immunofluorescence labeling for cytokeratin 5 showed that basal cells are absent at birth. They progressively appear in a retrograde manner from the VD and cauda epididymis to the initial segments during the postnatal weeks PNW1-3. At the onset of differentiation, basal cells are in contact with the lumen and their nucleus is located at the same level as that of adjacent epithelial cells. Basal cells then position their nucleus to the base of the epithelium, and while some are still in contact with the lumen, others have a 'dome-shaped' appearance. At PNW5-6, basal cells form a loose network at the base of the epithelium, and luminal-reaching basal cells are rarely detected. The arrival of spermatozoa during PNW7-8 did not trigger the development of projections in basal cells. However, cells with a narrow luminal-reaching projection began to reappear between PNW8 and PNW12 in the corpus and the cauda. Treatment with flutamide from PNW10 to PNW12 significantly reduced the number of luminal-reaching basal cell projections. In summary, basal cells exhibit significant structural plasticity during differentiation. Fewer apical-reaching projections were detected after flutamide treatment in adulthood, indicating the role of androgens in the luminal-sensing function of basal cells.
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