ArticleEndocrinology2013
Restoration of dopamine signaling to the dorsal striatum is sufficient for aspects of active maternal behavior in female mice.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- I've got a friend somewhere: control of social behavior across striatal subregions.Frontiers in behavioral neuroscience · 2026Review
- Dopamine dynamics underlying maternal motivation and reward.Neuroscience research · 2025Review
- Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice.Nature communications · 2025Article
- Orbitofrontal cortex influences dopamine dynamics associated with alloparental behavioral acquisition in female mice.Science advances · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Article
- Keeping Track of the Genealogy of Heterozygotes Using Epigenetic Reference Codes and Breeding Tables.Frontiers in behavioral neuroscience · 2021Article
- Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams.Scientific reports · 2020Article
- Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.Genes, brain, and behavior · 2020Article
- How ovarian hormones influence the behavioral activation and inhibition system through the dopamine pathway.PloS one · 2020Article
- Maternal care boosted by paternal imprinting in mammals.PLoS biology · 2018Article
- Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation.Frontiers in endocrinology · 2018Review
- Gestational Exposure to the Synthetic Cathinone Methylenedioxypyrovalerone Results in Reduced Maternal Care and Behavioral Alterations in Mouse Pups.Frontiers in neuroscience · 2018Article
- Flow cytometric evaluation of crude synaptosome preparation as a way to study synaptic alteration in neurodegenerative diseases.Neuromethods · 2018Article
- A new brain dopamine-deficient Drosophila and its pharmacological and genetic rescue.Genes, brain, and behavior · 2017Article
- Inactivation of the melanin concentrating hormone system impairs maternal behavior.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core.Endocrinology · 2016Article
- Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.Epigenomics · 2016Article
- Relative contributions of severe dopaminergic neuron ablation and dopamine depletion to cognitive impairment.Experimental neurology · 2015Article
- Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammals.Hormones and behavior · 2015Review
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3 authors.
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Abstract
Striatal dopamine (DA) is important for motivated behaviors, including maternal behavior. Recent evidence linking the dorsal striatum with goal-directed behavior suggests that DA signaling in the dorsal striatum, not just the nucleus accumbens, could be involved in maternal behavior. To investigate this question, we tested the maternal behavior of mice with DA genetically restricted to the dorsal striatum. These mice had a mild deficit in pup retrieval but had normal licking/grooming and nursing behavior; consequently, pups were weaned successfully. We also tested a separate group of mice with severely depleted DA in all striatal areas. They had severe deficits in pup retrieval and licking/grooming behavior, whereas nursing behavior was left intact; again, pups survived to weaning at normal rates. We conclude that DA signaling in the striatum is a part of the circuitry mediating maternal behavior and is specifically relevant for active, but not passive, maternal behaviors. In addition, DA in the dorsal striatum is sufficient to allow for active maternal behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.