ArticleProceedings of the National Academy of Sciences of the United States of America2013
Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Article
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- Multiple Precursor Proteins of Thanatin Isoforms, an Antimicrobial Peptide Associated With the Gut Symbiont ofFrontiers in microbiology · 2021Article
- Neurotransmitters Affect Larval Development by Regulating the Activity of Prothoracicotropic Hormone-Releasing Neurons inFrontiers in neuroscience · 2021Article
- Insulin-Like Signalling Influences the Coordination of Larval Hemocyte Number with Body Size inG3 (Bethesda, Md.) · 2020Article
- Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq.BMC genomics · 2020Article
- The β-oxidation pathway is downregulated during diapause termination in Calanus copepods.Scientific reports · 2019Article
- TheBiology open · 2019Article
- Structure-function characterization of an insecticidal protein GNIP1Aa, a member of an MACPF and β-tripod families.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Hormonal signaling cascades required for phototaxis switch in wandering Leptinotarsa decemlineata larvae.PLoS genetics · 2019Article
- The trigger (and the restriction) of Torso RTK activation.Open biology · 2018Review
- A quantitative model of developmental RTK signaling.Developmental biology · 2018Review
- Holes in the Plasma Membrane Mimic Torso-Like Perforin in Torso Tyrosine Kinase Receptor Activation in theGenetics · 2018Article
- Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway inGenetics · 2018Article
- Genome-Wide Screen for New Components of theG3 (Bethesda, Md.) · 2018Article
- Maternal Torso-Like Coordinates Tissue Folding DuringGenetics · 2017Article
- Myostatin-like proteins regulate synaptic function and neuronal morphology.Development (Cambridge, England) · 2017Article
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.Development (Cambridge, England) · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the Drosophila receptor tyrosine kinase Torso (Tor) only at the termini of the embryo is achieved by the localized expression of the maternal gene Torso-like (Tsl). Tor has a second function in the prothoracic gland as the receptor for prothoracicotropic hormone (PTTH) that initiates metamorphosis. Consistent with the function of Tor in this tissue, Tsl also localizes to the prothoracic gland and influences developmental timing. Despite these commonalities, in our studies of Tsl we unexpectedly found that tsl and tor have opposing effects on body size; tsl null mutants are smaller than normal, rather than larger as would be expected if the PTTH/Tor pathway was disrupted. We further found that whereas both genes regulate developmental timing, tsl does so independently of tor. Although tsl null mutants exhibit a similar length delay in time to pupariation to tor mutants, in tsl:tor double mutants this delay is strikingly enhanced. Thus, loss of tsl is additive rather than epistatic to loss of tor. We also find that phenotypes generated by ectopic PTTH expression are independent of tsl. Finally, we show that a modified form of tsl that can rescue developmental timing cannot rescue terminal patterning, indicating that Tsl can function via distinct mechanisms in different contexts. We conclude that Tsl is not just a specialized cue for Torso signaling but also acts independently of PTTH/Tor in the control of body size and the timing of developmental progression. These data highlight surprisingly diverse developmental functions for this sole Drosophila member of the perforin-like superfamily.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.