ArticleThe Journal of physiology2013
The role of myogenic mechanisms in human cerebrovascular regulation.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- A systematic review, meta-analysisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Calcium Channel Blockers in Acute Care: The Links and Missing Links Between Hemodynamic Effects and Outcome Evidence.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Pooled it
- Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation.Stroke · 2014Trial
- Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation.NPJ digital medicine · 2026Article
- Quantification of the cerebral pressure-flow relationship directional sensitivity: Reliability of shorter repeated squat-stand durations.Experimental physiology · 2026Article
- Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.Sports medicine (Auckland, N.Z.) · 2026Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Age-Related Alterations of Cerebral Autoregulation.Life (Basel, Switzerland) · 2025Review
- Intracerebral Hemorrhage in Aging: Pathophysiology, Clinical Challenges, and Future Directions.Life (Basel, Switzerland) · 2025Review
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells.Neurophotonics · 2025Article
- Examining the upper frequency limit of dynamic cerebral autoregulation: Considerations across the cardiac cycle during eucapnia.Experimental physiology · 2024Article
- Review
- Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Nervous System Response to Neurotrauma: A Narrative Review of Cerebrovascular and Cellular Changes After Neurotrauma.Journal of molecular neuroscience : MN · 2024Review
- Validity and reliability of deriving the autoregulatory plateau through projection pursuit regression from driven methods.Physiological reports · 2024Article
- Quantification of dynamic cerebral autoregulation: welcome to the jungle!Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Point-Counterpoint: Transfer function analysis of dynamic cerebral autoregulation: To band or not to band?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Regulation of cerebrovascular compliance compared with forearm vascular compliance in humans: a pharmacological study.American journal of physiology. Heart and circulatory physiology · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although myogenic mechanisms have been hypothesized to play a role in cerebrovascular regulation, previous data from both animals and humans have not provided an unequivocal answer. However, cerebral autoregulation is explicitly non-linear and most prior work relied on simple linear approaches for assessment, potentially missing important changes in autoregulatory characteristics. Therefore, we examined cerebral blood flow responses to augmented arterial pressure oscillations with and without calcium channel blockade (nicardipine) during blood pressure fluctuations (oscillatory lower body negative pressure, OLBNP) across a range of frequencies in 16 healthy subjects. Autoregulation was characterized via a robust non-linear method (projection pursuit regression, PPR). Blockade resulted in significant tachycardia, a modest but significant elevation in mean arterial pressure, and reductions in mean cerebral blood flow and end-tidal CO2 during OLBNP. The reductions in flow were directly related to the reductions in CO2 (r = 0.57). While linear cross-spectral analysis showed that the relationship between pressure-flow fluctuations was preserved after blockade, PPR showed that blockade significantly altered the non-linearity between pressure and flow, particularly at the slowest fluctuations. At 0.03 Hz, blockade reduced the range of pressure fluctuations that can be buffered (7.5 ± 1.0 vs. 3.7 ± 0.8 mmHg) while increasing the autoregulatory slope (0.10 ± 0.05 vs. 0.24 ± 0.08 cm s(-1) mmHg(-1)). Furthermore, the same rate of change in pressure elicited a change in flow more than twice as large as at baseline. Thus, our results show that myogenic mechanisms play a significant role in cerebrovascular regulation but this may not be appreciated without adequately characterizing the non-linearities inherent in cerebrovascular regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.