ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
Bone strength and structural deficits in children and adolescents with a distal forearm fracture resulting from mild trauma.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
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- The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography.Frontiers in endocrinology · 2026Article
- Bone health: Quality versus quantity.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging.Current osteoporosis reports · 2023Review
- Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations.Current osteoporosis reports · 2023Review
- The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019Review
- Deficits in Bone Geometry in Growth Hormone-Deficient Prepubertal Boys Revealed by High-Resolution Peripheral Quantitative Computed Tomography.Hormone research in paediatrics · 2019Article
- Finite element modelling of the developing infant femur using paired CT and MRI scans.PloS one · 2019Article
- Fat and bone in children - where are we now?Annals of pediatric endocrinology & metabolism · 2018Article
- Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Precision of bone density and micro-architectural properties at the distal radius and tibia in children: an HR-pQCT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Do bone mineral content and density determine fracture in children? A possible threshold for physical activity.Pediatric research · 2017Article
- Molecular diagnosis in children with fractures but no extraskeletal signs of osteogenesis imperfecta.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children.Calcified tissue international · 2017Review
- Prevalence of Fracture in Healthy Iranian Children Aged 9-18 Years and Associated Risk Factors; A Population Based Study.Bulletin of emergency and trauma · 2017Article
- Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture.Journal of endocrinological investigation · 2016Article
- Prevalence of vitamin D insufficiency among adolescents and its correlation with bone parameters using high-resolution peripheral quantitative computed tomography.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Increasing wrist fracture rates in children may have major implications for future adult fracture burden.Acta orthopaedica · 2016Article
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8 authors at 2 institutions in 2 countries.
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Abstract
Although distal forearm fractures (DFFs) are common during childhood and adolescence, it is unclear whether they reflect underlying skeletal deficits or are simply a consequence of the usual physical activities, and associated trauma, during growth. Therefore, we examined whether a recent DFF, resulting from mild or moderate trauma, is related to deficits in bone strength and cortical and trabecular bone macro- and microstructure compared with nonfracture controls. High-resolution peripheral quantitative computed tomography was used to assess micro-finite element-derived bone strength (ie, failure load) and to measure cortical and trabecular bone parameters at the distal radius and tibia in 115 boys and girls with a recent (<1 year) DFF and 108 nonfracture controls aged 8 to 15 years. Trauma levels (mild versus moderate) were assigned based on a validated classification scheme. Compared with sex-matched controls, boys and girls with a mild-trauma DFF (eg, fall from standing height) showed significant deficits at the distal radius in failure load (-13% and -11%, respectively; p < 0.05) and had higher ("worse") fall load-to-strength ratios (both +10%; p < 0.05 for boys and p = 0.06 for girls). In addition, boys and girls with a mild-trauma DFF had significant reductions in cortical area (-26% and -23%, respectively; p < 0.01) and cortical thickness (-14% and -13%, respectively; p < 0.01) compared with controls. The skeletal deficits in the mild-trauma DFF patients were generalized, as similar changes were present at the distal tibia. By contrast, both boys and girls with a moderate-trauma DFF (eg, fall from a bicycle) had virtually identical values for all of the measured bone parameters compared with controls. In conclusion, DFFs during growth have two distinct etiologies: those owing to underlying skeletal deficits leading to fractures with mild trauma versus those owing to more significant trauma in the setting of normal bone strength.
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