ArticleScientific reports2013
Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Growth dynamics of breast cancer stem cells: effects of self-feedback and EMT mechanisms.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Cancer resistance to immunotherapy: What is the role of cancer stem cells?Cancer drug resistance (Alhambra, Calif.) · 2022Review
- It's about time: Analysing simplifying assumptions for modelling multi-step pathways in systems biology.PLoS computational biology · 2020Article
- Review
- Identification of Immune-Related Therapeutically Relevant Biomarkers in Breast Cancer and Breast Cancer Stem Cells by Transcriptome-Wide Analysis: A Clinical Prospective Study.Frontiers in oncology · 2020Article
- Evaluation of pancreatic tumor development in KPC mice using multi-parametric MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- The complex ecosystem in non small cell lung cancer invasion.PLoS computational biology · 2018Article
- Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells.Carcinogenesis · 2018Article
- A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.PLoS computational biology · 2018Article
- HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer.Molecular cancer therapeutics · 2017Article
- The role of backward cell migration in two-hit mutants' production in the stem cell niche.PloS one · 2017Article
- Controlling Stochasticity in Epithelial-Mesenchymal Transition Through Multiple Intermediate Cellular States.Discrete and continuous dynamical systems. Series B · 2016Article
- Quantifying the landscape and kinetic paths for epithelial-mesenchymal transition from a core circuit.Physical chemistry chemical physics : PCCP · 2016Article
- Mathematical models of breast and ovarian cancers.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Delayed Onset of Symptoms Through Feedback Interference in Chronic Cancers.Convergent science physical oncology · 2016Article
- Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.Molecular medicine reports · 2015Article
- A versatile mathematical work-flow to explore how Cancer Stem Cell fate influences tumor progression.BMC systems biology · 2015Article
- Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models.Frontiers in oncology · 2015Review
- Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: novel therapeutic strategy for aggressive breast cancers.Molecular cancer therapeutics · 2014Article
- Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals.Oncotarget · 2014Article
Corrections and comments
- Erratum issuedSingn, Udai [corrected to Singh, Udai P]
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Cancer stem cells (CSCs) have been identified in primary breast cancer tissues and cell lines. The CSC population varies widely among cancerous tissues and cell lines, and is often associated with aggressive breast cancers. Despite of intensive research, how the CSC population is regulated within a tumor is still not well understood so far. In this paper, we present a mathematical model to explore the growth kinetics of CSC population both in vitro and in vivo. Our mathematical models and supporting experiments suggest that there exist non-linear growth kinetics of CSCs and negative feedback mechanisms to control the balance between the population of CSCs and that of non-stem cancer cells. The model predictions can help us explain a few long-standing questions in the field of cancer stem cell research, and can be potentially used to predict the efficicacy of anti-cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.