ArticleEpigenetics2014
Prenatal stress changes the glycoprotein GPM6A gene expression and induces epigenetic changes in rat offspring brain.
Article in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Chronic prenatal corticosterone exposure alters postpartum maternal behavior and shapes sex-specific offspring outcomes.Research square · 2026Article
- Research advances on the impact of gestational diabetes mellitus on offspring neurodevelopment.Diabetology & metabolic syndrome · 2026Review
- Perinatal Psychoneuroimmunology of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genomic insights into runs of homozygosity, effective population size and selection signatures in Iranian meat and dairy sheep breeds.PloS one · 2025Article
- Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats.Neurobiology of stress · 2024Article
- Article
- Review
- Cell-type-specific epigenetic effects of early life stress on the brain.Translational psychiatry · 2022Review
- Survival stratification for colorectal cancer via multi-omics integration using an autoencoder-based model.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress.Current neuropharmacology · 2022Article
- Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats.Molecular neurobiology · 2021Article
- Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers.Translational psychiatry · 2021Review
- microRNAs and Gene-Environment Interactions in Autism: Effects of Prenatal Maternal Stress and theFrontiers in psychiatry · 2021Article
- Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction.Frontiers in synaptic neuroscience · 2021Review
- Survival prediction in patients with colon adenocarcinoma via multi-omics data integration using a deep learning algorithm.Bioscience reports · 2020Article
- The epigenetics of perinatal stress .Dialogues in clinical neuroscience · 2019Review
- Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention.Current pharmaceutical design · 2019Review
- Epigenetic modulation during hippocampal development.Biomedical reports · 2018Review
- PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat.Archives of toxicology · 2018Article
- Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders.Current psychiatry reports · 2018Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal stress (PS) exerts strong impact on fetal brain development and on adult offspring brain functions. Previous work demonstrated that chronic stress alters the mRNA expression of GPM6A, a neuronal glycoprotein involved in filopodium extension. In this work, we analyzed the effect of PS on gpm6a expression and the epigenetic mechanisms involved. Pregnant Wistar rats received restraint stress during the last week of gestation. Male offspring were sacrificed on postnatal days 28 and 60. Hippocampus and prefrontal cortex samples were analyzed for gene expression (qPCR for mRNAs and microRNAs), methylation status (bisulfite conversion) and protein levels. Hippocampal neurons in culture were used to analyze microRNA overexpression effects. Prenatal stress induced changes in gpm6a levels in both tissues and at both ages analyzed, indicating a persistent effect. Two CpG islands in the gpm6a gene were identified. Variations in the methylation pattern at three specific CpGs were found in hippocampus, but not in PFC samples from PS offspring. microRNAs predicted to target gpm6a were identified in silico. qPCR measurements showed that PS modified the expression of several microRNAs in both tissues, being microRNA-133b the most significantly altered. Further studies overexpressing this microRNA in neuronal cultures showed a reduction in gmp6a mRNA and protein level. Moreover filopodium density was also reduced, suggesting that GPM6A function was affected. Gestational stress affected gpm6a gene expression in offspring likely through changes in methylation status and in posttranscriptional regulation by microRNAs. Thus, our findings propose gpm6a as a novel target for epigenetic regulation during prenatal stress.
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