ArticleThe American journal of tropical medicine and hygiene2013
The attenuated nine mile phase II clone 4/RSA439 strain of Coxiella burnetii is highly virulent for severe combined immunodeficient (SCID) mice.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Direct whole-genome sequencing of Coxiella burnetii from environmental samples using a two-step selective enrichment approach.PLoS neglected tropical diseases · 2026Article
- Bioluminescent imaging to investigateInfection and immunity · 2025Article
- Overview of the Q fever vaccine development: current status and future prospects.Antonie van Leeuwenhoek · 2025Review
- Role of Type 4B Secretion System Protein, IcmE, in the Pathogenesis ofPathogens (Basel, Switzerland) · 2024Article
- Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain.Nature communications · 2024Article
- Characterization ofMicroorganisms · 2022Article
- Coxiella burnetii-Infected NK Cells Release Infectious Bacteria by Degranulation.Infection and immunity · 2020Article
- MyD88 Is Required for Efficient Control ofFrontiers in immunology · 2019Article
- Characterization ofNew microbes and new infections · 2018Article
- Host and Bacterial Factors Control Susceptibility of Drosophila melanogaster to Coxiella burnetii Infection.Infection and immunity · 2017Article
- The SCID Mouse Model for Identifying Virulence Determinants inFrontiers in cellular and infection microbiology · 2017Article
- Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions.Future microbiology · 2016Review
- Bayesian Validation of the Indirect Immunofluorescence Assay and Its Superiority to the Enzyme-Linked Immunosorbent Assay and the Complement Fixation Test for Detecting Antibodies against Coxiella burnetii in Goat Serum.Clinical and vaccine immunology : CVI · 2016Article
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Abstract
The Nine Mile phase II clone 4 (NMIIC4) strain of Coxiella burnetii is an attenuated phase II strain that has lost the genes for virulence determinant type 1 lipopolysaccharide. These bacteria were very virulent for severe combined immunodeficient (SCID) mice. The lethal dose 50 (LD50) was ~10 bacteria. Infected SCID mice died between Day 28 and Day 53 post-infection. At termination of the experiment (Day 60) only 5 of 24 mice had survived. The degree of splenomegaly was directly related to the bacterial load in the SCID mice spleens. The NMIIC4 was avirulent in immunocompetent wild mice and bacterial DNA copies in splenic tissue were extremely low. The SCID mice that were inoculated with high doses of heat inactivated NMIIC4 C. burnetii were all alive at Day 60 and without splenomegaly. It appears that the phase I lipopolysaccharide present in virulent Nine Mile phase I but not in attenuated NMIIC4 is not the only virulence factor for C. burnetii.
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