ReviewNature reviews. Rheumatology2013
Insights from human genetic studies into the pathways involved in osteoarthritis.
Review in Nature reviews. Rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity.Journal of orthopaedic surgery and research · 2017Pooled it
- Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects.BMC musculoskeletal disorders · 2014Pooled it
- Relationship between Feline Knee Joint Osteoarthritis and Bone Mineral Density Quantified Using Computed Tomography and Computed Digital Absorptiometry.Animals : an open access journal from MDPI · 2024Article
- Molecular Mechanisms Linking Osteoarthritis and Alzheimer's Disease: Shared Pathways, Mechanisms and Breakthrough Prospects.International journal of molecular sciences · 2024Review
- Inflammaging and Osteoarthritis.Clinical reviews in allergy & immunology · 2023Review
- Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis.Life (Basel, Switzerland) · 2022Review
- Evolutionary insights into primate skeletal gene regulation using a comparative cell culture model.PLoS genetics · 2022Article
- Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics.Frontiers in cellular and infection microbiology · 2022Review
- Article
- Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models.Biology · 2020Review
- Identification of a potential gene target for osteoarthritis based on bioinformatics analyses.Journal of orthopaedic surgery and research · 2020Article
- Duration of symptoms prior to partial meniscectomy is not associated with the expression of osteoarthritis genes in the injured meniscus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Assessing the genetic relationships between osteoarthritis and human plasma proteins: a large scale genetic correlation scan.Annals of translational medicine · 2020Article
- Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.JCI insight · 2019Article
- Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications fromJournal of biosciences · 2019Article
- Alteration of the Total Cellular Glycome during Late Differentiation of Chondrocytes.International journal of molecular sciences · 2019Article
- Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients.Scientific reports · 2019Article
- Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis.Osteoarthritis and cartilage · 2019Article
- miRNA-101 promotes chondrogenic differentiation in rat bone marrow mesenchymal stem cells.Experimental and therapeutic medicine · 2019Article
- Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Genetic studies have revealed that most loci associated with osteoarthritis (OA) show ethnic stratification, with limited overlap between Asian and European populations. Consequently, such studies have often focused on particular ethnic groups, with those performed in European cohorts yielding the most replicated associations. As for other common diseases, the OA susceptibility loci mapped to date account for only a fraction of disease heritability. Nevertheless, analysis of these loci could identify biological pathways related to OA pathogenesis. Such an approach is taken in this Review and provides valuable insights into OA aetiology. For example, several of the loci associated with OA contain genes encoding key regulators of skeletogenesis and endochondral ossification. Furthermore, direct and indirect regulation of gene transcription is highlighted as an important factor in this disease. Interestingly, genes encoding structural proteins of the cartilage extracellular matrix do not seem to be a repository for OA susceptibility. Therefore, susceptibility might operate at a regulatory rather than a structural level, which is a potentially promising finding, as the activities of regulators are amenable to therapeutic modulation. Greater clarity will emerge as more association signals are identified; nonetheless, patterns of aetiology are clearly discernible, from a molecular perspective, even with the relatively small number currently available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.