ArticleParticle and fibre toxicology2013
Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice.
Article in Particle and fibre toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A Systematic Review on the Hazard Assessment of Amorphous Silica Based on the Literature From 2013 to 2018.Frontiers in public health · 2022Pooled it
- Expandable Nanocomposite Shape-Memory Hemostat for the Treatment of Noncompressible Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gestational Intranasal Exposure to Silicon Dioxide Nanoparticles in Rats.International journal of nanomedicine · 2026Article
- Enhancement of hemostatic properties of Cyclotella cryptica frustule through genetic manipulation.Biotechnology for biofuels and bioproducts · 2023Article
- Studies on safety and efficacy of particles containing a mixture of hydroxyapatite-argentum-titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: II. Cellular, in vivo, and clinical studies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Silica Nanoparticles in Transmucosal Drug Delivery.Pharmaceutics · 2020Review
- Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis.International journal of molecular medicine · 2019Article
- Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.Nanotoxicology · 2018Article
- Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice.Nanoscale research letters · 2017Article
- Biocompatibility of Multi-Imaging Engineered Mesoporous Silica Nanoparticles:Journal of biomedical nanotechnology · 2017Article
- Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific.Frontiers in immunology · 2017Article
- Allergic Responses Induced by the Immunomodulatory Effects of Nanomaterials upon Skin Exposure.Frontiers in immunology · 2017Review
- Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation.Current medicinal chemistry · 2016Review
- Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets.Biochemistry research international · 2016Article
- Development of novel drug delivery systems using phage display technology for clinical application of protein drugs.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Review
- Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway.International journal of nanomedicine · 2015Article
- Evaluation of silica nanoparticle binding to major human blood proteins.Nanoscale research letters · 2014Article
- Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice.Particle and fibre toxicology · 2014Article
- Asian dust particles induce macrophage inflammatory responses via mitogen-activated protein kinase activation and reactive oxygen species production.Journal of immunology research · 2014Article
- Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro.Nanoscale research letters · 2014Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanomaterials with particle sizes <100 nm have been already applied in various applications such as cosmetics, medicines, and foods. Therefore, ensuring the safety of nanomaterials is becoming increasingly important. Here we examined the localization and biological responses of intranasally administered amorphous nanosilica particles in mice, focusing on the coagulation system.
methodsWe used nanosilica particles with diameters of 30, 70, or 100 nm (nSP30, nSP70, or nSP100 respectively), and conventional microscale silica particles with diameters of 300 or 1000 nm (mSP300 or mSP1000, respectively). BALB/c mice were intranasally exposed to nSP30, nSP70, nSP100, mSP300, or mSP1000 at concentrations of 500 μg/mouse for 7 days. After 24 hours of last administration, we performed the in vivo transmission electron microscopy analysis, hematological examination and coagulation tests.
resultsIn vivo transmission electron microscopy analysis showed that nanosilica particles with a diameter <100 nm were absorbed through the nasal cavity and were distributed into liver and brain. Hematological examination and coagulation tests showed that platelet counts decreased and that the activated partial thromboplastin time was prolonged in nSP30 or nSP70-treated groups of mice, indicating that nanosilica particles might have activated a coagulation cascade. In addition, in in vitro activation tests of human plasma, nanosilica particles had greater potential than did conventional microscale silica particles to activate coagulation factor XII. In nanosilica-particle-treated groups, the levels of soluble CD40 ligand, and von Willebrand factor which are involved in stimulating platelets tended to slightly increase with decreasing particle size.
conclusionsThese results suggest that intranasally administered nanosilica particles with diameters of 30 and 70 nm could induce abnormal activation of the coagulation system through the activation of an intrinsic coagulation cascade. This study provides information to advance the development of safe and effective nanosilica particles.
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