ArticleBiomaterials2013
Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 104 citations in OpenAlex.
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Untethered miniature robots for minimally invasive thrombus treatment: From bench to clinical trials.Innovation (Cambridge (Mass.)) · 2025Review
- Advanced Imaging Strategies Based on Intelligent Micro/Nanomotors.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- High-resolution and high-speed 3D tracking of microrobots using a fluorescent light field microscope.Quantitative imaging in medicine and surgery · 2023Article
- Medical micro- and nanomotors in the body.Acta pharmaceutica Sinica. B · 2023Review
- Tailoring Functional Micromotors for Sensing.Research (Washington, D.C.) · 2023Article
- Enzyme-powered micro- and nano-motors: key parameters for an application-oriented design.Chemical science · 2022Review
- The Energy Conversion behind Micro-and Nanomotors.Micromachines · 2021Review
- Medical Micro/Nanorobots in Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments.Biophysics reports · 2020Article
- Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy.Theranostics · 2019Article
- Biomolecular Ultrasound and Sonogenetics.Annual review of chemical and biomolecular engineering · 2018Review
- Recent progress on micro- and nano-robots: towardsQuantitative imaging in medicine and surgery · 2018Article
- How to Make a Fast, Efficient Bubble-Driven Micromotor: A Mechanical View.Micromachines · 2017Review
- Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles.Advanced healthcare materials · 2017Article
- 3D printed self-driven thumb-sized motors for in-situ underwater pollutant remediation.Scientific reports · 2017Article
- A HTheranostics · 2017Article
- Imaging Reactive Oxygen Species-Induced Modifications in Living Systems.Antioxidants & redox signaling · 2016Review
- Self-Guided Supramolecular Cargo-Loaded Nanomotors with Chemotactic Behavior towards Cells.Angewandte Chemie (International ed. in English) · 2015Article
- Chemical approaches to discovery and study of sources and targets of hydrogen peroxide redox signaling through NADPH oxidase proteins.Annual review of biochemistry · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
We present a new class of ultrasound molecular imaging agents that extend upon the design of micromotors that are designed to move through fluids by catalyzing hydrogen peroxide (H₂O₂) and propelling forward by escaping oxygen microbubbles. Micromotor converters require 62 mm of H₂O₂ to move - 1000-fold higher than is expected in vivo. Here, we aim to prove that ultrasound can detect the expelled microbubbles, to determine the minimum H₂O₂ concentration needed for microbubble detection, explore alternate designs to detect the H₂O₂ produced by activated neutrophils and perform preliminary in vivo testing. Oxygen microbubbles were detected by ultrasound at 2.5 mm H₂O₂. Best results were achieved with a 400-500 nm spherical design with alternating surface coatings of catalase and PSS over a silica core. The lowest detection limit of 10-100 μm was achieved when assays were done in plasma. Using this design, we detected the H₂O₂ produced by freshly isolated PMA-activated neutrophils allowing their distinction from naïve neutrophils. Finally, we were also able to show that direct injection of these nanospheres into an abscess in vivo enhanced ultrasound signal only when they contained catalase, and only when injected into an abscess, likely because of the elevated levels of H₂O₂ produced by inflammatory mediators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.