ArticleBMC biology2013
Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations.
Article in BMC biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 63 citations in OpenAlex.
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- The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.G3 (Bethesda, Md.) · 2024Article
- Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Nematode gene annotation by machine-learning-assisted proteotranscriptomics enables proteome-wide evolutionary analysis.Genome research · 2023Article
- An automated approach to quantify chemotaxis index inmicroPublication biology · 2022Article
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population.G3 (Bethesda, Md.) · 2021Article
- Natural variation in fecundity is correlated with species-wide levels of divergence in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2021Article
- Heat Stress Reduces the Susceptibility ofGenes · 2021Article
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- Preconditioning With Natural Microbiota StrainFrontiers in cellular and infection microbiology · 2021Article
- Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans.Communications biology · 2020Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity.BMC genomics · 2019Article
- A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits.BMC biology · 2019Article
- The Local Coexistence Pattern of Selfing Genotypes inGenetics · 2018Article
- Ras/MAPK Modifier Loci Revealed by eQTL inG3 (Bethesda, Md.) · 2017Article
- Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans.BMC genomics · 2017Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnalyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all studies, including forward and reverse genetic screens, are limited by investigations in only one canonical genotype. This hampers the detection and functional analysis of allelic variants, which play a key role in controlling many complex traits. It is therefore essential to explore the full potential of the natural genetic variation and evolutionary context of the genotype-phenotype map in wild C. elegans populations.
resultsWe used multiple wild C. elegans populations freshly isolated from local sites to investigate gene sequence polymorphisms and a multitude of phenotypes including the transcriptome, fitness, and behavioral traits. The genotype, transcriptome, and a number of fitness traits showed a direct link with the original site of the strains. The separation between the isolation sites was prevalent on all chromosomes, but chromosome V was the largest contributor to this variation. These results were supported by a differential food preference of the wild isolates for naturally co-existing bacterial species. Comparing polymorphic genes between the populations with a set of genes extracted from 19 different studies on gene expression in C. elegans exposed to biotic and abiotic factors, such as bacteria, osmotic pressure, and temperature, revealed a significant enrichment for genes involved in gene-environment interactions and protein degradation.
conclusionsWe found that wild C. elegans populations are characterized by gene-environment signatures, and we have unlocked a wealth of genotype-phenotype relations for the first time. Studying natural isolates provides a treasure trove of evidence compared with that unearthed by the current research in C. elegans, which covers only a diminutive part of the myriad of genotype-phenotype relations that are present in the wild.
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