ArticleBMC genomics2013
Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Metabolomics-Guided Genomic Comparisons Reveal Convergent Evolution of Hibernation Genes in Mammals.Molecular biology and evolution · 2025Article
- Periodic expression of Per1 gene is restored in chipmunk liver during interbout arousal in mammalian hibernation.Scientific reports · 2025Article
- Article
- Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction.Frontiers in neuroanatomy · 2024Article
- Blood transcriptomics mirror regulatory mechanisms during hibernation-a comparative analysis of the Djungarian hamster with other mammalian species.Pflugers Archiv : European journal of physiology · 2023Article
- Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold.Cells · 2023Review
- Differential AMPK-mediated metabolic regulation observed in hibernation-style polymorphisms in Siberian chipmunks.Frontiers in physiology · 2023Article
- Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation.Frontiers in pharmacology · 2023Review
- Performance of bat-derived macrophages at different temperatures.Frontiers in veterinary science · 2022Article
- Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.eLife · 2020Article
- Phagocyte activity reflects mammalian homeo- and hetero-thermic physiological states.BMC veterinary research · 2020Article
- Article
- Circadian transcription factor HSF1 regulates differential HSP70 gene transcription during the arousal-torpor cycle in mammalian hibernation.Scientific reports · 2019Article
- Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.Communications biology · 2019Article
- Inflammaging: a new immune-metabolic viewpoint for age-related diseases.Nature reviews. Endocrinology · 2018Review
- Regulation of Smad mediated microRNA transcriptional response in ground squirrels during hibernation.Molecular and cellular biochemistry · 2018Article
- Article
- Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application.Psychopharmacology · 2017Review
- Differential expression and emerging functions of non-coding RNAs in cold adaptation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Thermoregulation as a disease tolerance defense strategy.Pathogens and disease · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammalian hibernators display phenotypes similar to physiological responses to calorie restriction and fasting, sleep, cold exposure, and ischemia-reperfusion in non-hibernating species. Whether biochemical changes evident during hibernation have parallels in non-hibernating systems on molecular and genetic levels is unclear.
resultsWe identified the molecular signatures of torpor and arousal episodes during hibernation using a custom-designed microarray for the Arctic ground squirrel (Urocitellus parryii) and compared them with molecular signatures of selected mouse phenotypes. Our results indicate that differential gene expression related to metabolism during hibernation is associated with that during calorie restriction and that the nuclear receptor protein PPARα is potentially crucial for metabolic remodeling in torpor. Sleep-wake cycle-related and temperature response genes follow the same expression changes as during the torpor-arousal cycle. Increased fatty acid metabolism occurs during hibernation but not during ischemia-reperfusion injury in mice and, thus, might contribute to protection against ischemia-reperfusion during hibernation.
conclusionsIn this study, we systematically compared hibernation with alternative phenotypes to reveal novel mechanisms that might be used therapeutically in human pathological conditions.
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