ArticleBioconjugate chemistry2013
Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy.
Article in Bioconjugate chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 116 citations in OpenAlex.
- Artificial recombinant high-density protein nanocarriers for precision drug delivery.Chemical science · 2026Review
- Zinc-Based Nanoparticles, but Not Silicon-Based Nanoparticles, Accumulate in Mitochondria and Promote Cell Death in Liver Cancer Cells.International journal of nanomedicine · 2024Article
- Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer.AAPS PharmSciTech · 2023Review
- Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications.International journal of molecular sciences · 2022Review
- coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid-Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications.Biomedicines · 2022Article
- Towards principled design of cancer nanomedicine to accelerate clinical translation.Materials today. Bio · 2022Review
- PLGA Nanoparticle-Based Formulations to Cross the Blood-Brain Barrier for Drug Delivery: From R&D to cGMP.Pharmaceutics · 2021Review
- Enriched Au nanoclusters with mesoporous silica nanoparticles for improved fluorescence/computed tomography dual-modal imaging.Cell proliferation · 2021Article
- Polymer-Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies.Pharmaceutics · 2021Review
- Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment.Biomacromolecules · 2020Article
- Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers.Beilstein journal of organic chemistry · 2020Article
- Microfluidic assisted synthesis of PLGA drug delivery systems.RSC advances · 2019Review
- Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications.International journal of nanomedicine · 2019Review
- A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging.Nanoscale advances · 2019Article
- Hybrid magneto-plasmonic liposomes for multimodal image-guided and brain-targeted HIV treatment.Nanoscale · 2017Article
- Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices.Lab on a chip · 2017Article
- Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.Bioconjugate chemistry · 2017Article
- Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation.International journal of molecular sciences · 2017Review
- Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery.International journal of nanomedicine · 2017Article
- Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging.Journal of nanobiotechnology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
For advanced treatment of diseases such as cancer, multicomponent, multifunctional nanoparticles hold great promise. In the current study we report the synthesis of a complex nanoparticle (NP) system with dual drug loading as well as diagnostic properties. To that aim we present a methodology where chemically modified poly(lactic-co-glycolic) acid (PLGA) polymer is formulated into a polymer-lipid NP that contains a cytotoxic drug doxorubicin (DOX) in the polymeric core and an anti-angiogenic drug sorafenib (SRF) in the lipidic corona. The NP core also contains gold nanocrystals (AuNCs) for imaging purposes and cyclodextrin molecules to maximize the DOX encapsulation in the NP core. In addition, a near-infrared (NIR) Cy7 dye was incorporated in the coating. To fabricate the NP we used a microfluidics-based technique that offers unique NP synthesis conditions, which allowed for encapsulation and fine-tuning of optimal ratios of all the NP components. NP phantoms could be visualized with computed tomography (CT) and near-infrared (NIR) fluorescence imaging. We observed timed release of the encapsulated drugs, with fast release of the corona drug SRF and delayed release of a core drug DOX. In tumor bearing mice intravenously administered NPs were found to accumulate at the tumor site by fluorescence imaging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.