Evidence map›Paper›PMID 23957526›Full record

Trial reportAlimentary pharmacology & therapeutics2013

Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis.

L Keefer, T H Taft, J L Kiebles, Z Martinovich, T A Barrett, O S Palsson

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alimentary pharmacology & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00798642 (National Center for Complementary & Alternative Medicine, The Role of Gut-Directed Hypnotherapy in Relapse Prevention for Ulcerative Colitis), which is not on this map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00798642 nacompletednot on this map

National Center for Complementary & Alternative Medicine, The Role of Gut-Directed Hypnotherapy in Relapse Prevention for Ulcerative Colitis

TypeinterventionalSponsorNorthwestern UniversityRan2007 to 2012Enrolled55ConditionsUlcerative Colitis, Inflammatory Bowel DiseaseArmsHypnotherapy, Standard care, Mind Body Therapy
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
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  6. A Systematic Review of Self-Management Interventions for Inflammatory Bowel Disease.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2016
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

L KeeferDivision of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. laurie.keefer@northwestern.edu
T H Taft
J L Kiebles
Z Martinovich
T A Barrett
O S Palsson
Northwestern University · USEdward Hines, Jr. VA Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

THE ROLE OF GUT-DIRECTED HYPNOTHERAPY IN RELAPSE PREVENTION FOR ULCERATIVE COLITIR21AT003204 · NCCIH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEEFER, LAURIE A · 2008 to 2010
$625k
NCCIH NIH HHS R21AT0032004NCCIH NIH HHS R21 AT003204
6 · The paper itself

Abstract

backgroundPsychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut-directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune-mediated pathways in chronic diseases.

aimsTo determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1-year period in patients with an historical flare rate of 1.3 times per year.

methodsA total of 54 patients were randomised at a single site to seven sessions of gut-directed HYP (n = 26) or attention control (CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment.

resultsOne-way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [F = 4.8 (1, 48), P = 0.03] by 78 days. Chi-squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [χ²(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors.

conclusionThis is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642).

Indexed as

AdultColitis, UlcerativeFeasibility StudiesFemaleHumansHypnosisMaleMedication AdherenceMiddle AgedProspective StudiesRecurrenceRemission InductionTreatment Outcome

Identifiers

PMID23957526
PMCPMC4271841
OpenAlexW1991923515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.