ArticlePain research & management
Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients.
Article in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Cytokines in primary headache disorders: a systematic review and meta-analysis.The journal of headache and pain · 2023Pooled it
- Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- Cardiorespiratory fitness and pain severity: Longitudinal associations from the general population-The HUNT study.Pain reports · 2026Article
- MRGPRX2 as a novel therapeutic target in headache.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- The Convergence of Ancient Medical Wisdom and Modern Physiology: Sodium Ion Wave Propagation in Endothelial Cells, IL-1 Vascular Pathways, and the Six-Day Progression Pattern of Clinical Symptoms.Advances in experimental medicine and biology · 2026Review
- Hallmarks of primary headache: part 2- Tension-type headache.The journal of headache and pain · 2025Review
- Serum cytokines in primary new daily persistent headache and chronic migraine: a case control study.Frontiers in neurology · 2025Article
- A mouse model of chronic primary pain that integrates clinically relevant genetic vulnerability, stress, and minor injury.Science translational medicine · 2024Article
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
- Acute panuveitis after COVID-19 mRNA booster vaccination following cataract surgery.American journal of ophthalmology case reports · 2022Article
- Network Pharmacology-Based Investigation on Therapeutic Mechanisms of thePlants (Basel, Switzerland) · 2022Article
- Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?Medicines (Basel, Switzerland) · 2022Review
- Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms.Journal of neuroinflammation · 2021Review
- Review
- Potential of Point-of-Care and At-Home Assessment of Immune Status via Rapid Cytokine Detection and Questionnaire-Based Anamnesis.Sensors (Basel, Switzerland) · 2021Article
- Sustained stimulation of βBrain, behavior, and immunity · 2018Article
- ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood-Brain Barrier Function in Neonatal-Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal-Onset Multisystem Inflammatory Disease Correlate With Central Nervous System Inflammation.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration.Open access Macedonian journal of medical sciences · 2017Article
- Biomarkers for Chronic Neuropathic Pain and their Potential Application in Spinal Cord Stimulation: A Review.Translational perioperative and pain medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH.
objectivesTo determine the role of peripheral cytokines and genetic factors in the development of CTTH.
methodsA panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age.
resultsLevels of interleukin (IL)-1β were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1β gene.
conclusionsThese findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation.
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