ArticleCommunicative & integrative biology2013
QTL clustering as a mechanism for rapid multi-trait evolution.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Analysis of multi-trait evolution across independently evolved cavefish populations reveals shared and independent evolution of suites of traits.Proceedings. Biological sciences · 2026Article
- Analysis of multi-trait evolution across independently evolved cavefish populations reveals shared and independent evolution of suites of cave-associated traits.bioRxiv : the preprint server for biology · 2025Article
- Genetics of adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Development of a High-Density Genetic Map Based on Specific Length Amplified Fragment Sequencing and Its Application in Quantitative Trait Loci Analysis for Yield-Related Traits in Cultivated Peanut.Frontiers in plant science · 2018Article
- The Integrated Genomic Architecture and Evolution of Dental Divergence in East African Cichlid Fishes (G3 (Bethesda, Md.) · 2017Article
- Genetic mapping of yield traits using RIL population derived from Fuchuan Dahuasheng and ICG6375 of peanut (Molecular breeding : new strategies in plant improvement · 2017Article
- A pleiotropic interaction between vision loss and hypermelanism in Astyanax mexicanus cave x surface hybrids.BMC evolutionary biology · 2016Article
- The sensitivity of lateral line receptors and their role in the behavior of Mexican blind cavefish (Astyanax mexicanus).The Journal of experimental biology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cave-dwelling animals exhibit remarkable convergence in multiple cave-related traits, yet the genetic mechanisms responsible for the evolution and integration of many such traits remain unclear. Astyanax mexicanus is a model cave-dwelling fish with sighted surface-dwelling (surface fish) and blind cave-dwelling (cavefish) forms. Using a genetic cross between these morphs, we discovered significant correlations among several cave-related traits, including reduced eyes, increased superficial neuromast receptors located within the eye orbit (EO SN) and a vibration-attraction behavior (VAB) that facilitates foraging in darkness. Furthermore, we discovered that the quantitative trait loci (QTL) underlying these traits are clustered within the Astyanax genome. Following an ablation experiment that demonstrated that the EO SN contribute to VAB, we concluded that the adaptive evolution of VAB and EO SN has likely contributed to eye loss in cavefish. In this addendum, we further discuss the possible role of multi-trait QTL clustering in facilitating rapid adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.