ArticleBiological research for nursing2014
Suppression of natural killer cell cytotoxicity in postpartum women: time course and potential mechanisms.
Article in Biological research for nursing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis.AIDS (London, England) · 2020Pooled it
- Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV prevention package among breastfeeding women in Malawi.BMC health services research · 2025Trial
- DELIVER: A Safety Study of a Dapivirine Vaginal Ring and Oral PrEP for the Prevention of HIV During Pregnancy.Journal of acquired immune deficiency syndromes (1999) · 2024Trial
- Increased Risk of HIV Acquisition Among Women Throughout Pregnancy and During the Postpartum Period: A Prospective Per-Coital-Act Analysis Among Women With HIV-Infected Partners.The Journal of infectious diseases · 2018Trial
- Inflammation, antiretroviral therapy continuation, and HIV disease progression in postpartum women with HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- PBPK-Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population.CPT: pharmacometrics & systems pharmacology · 2025Article
- Influence of Breastfeeding on the State of Meta-Inflammation in Obesity-A Narrative Review.Current issues in molecular biology · 2023Review
- Biomarkers of Postpartum Depression: A Narrative Review.Journal of clinical medicine · 2023Review
- An update on thyroid disorders in the postpartum period.Journal of endocrinological investigation · 2022Review
- Association Between Breastfeeding and Ovarian Cancer Risk.JAMA oncology · 2020Article
- Relationship of Anxiety, Inflammation, and Telomere Length in Postpartum Women: A Pilot Study.Biological research for nursing · 2020Article
- The impact of previous live births on peripheral and uterine natural killer cells in patients with recurrent miscarriage.Reproductive biology and endocrinology : RB&E · 2019Article
- Graves' Disease and the Post-partum Period: An Intriguing Relationship.Frontiers in endocrinology · 2019Review
- Postpartum Mood Disorders and Thyroid Autoimmunity.Frontiers in endocrinology · 2017Article
- Women and primary biliary cirrhosis.Clinical reviews in allergy & immunology · 2015Review
- Immune changes and dysphoric moods across the postpartum.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the recovery of the immune system from normal pregnancy and whether the postpartum period is a uniquely adapted immune state. This report extends previous observations from our group of decreased natural killer (NK) cell cytotoxicity in the postpartum period. NK cytotoxicity was measured from 1 week through 9 months postpartum. In addition, NK cytotoxicity was assayed in the presence or absence of pooled plasmas collected from either postpartum or nonpostpartum women. Samples of cells were stained for inhibitory receptors and analyzed by flow cytometry. NK cytotoxicity remained decreased in postpartum women compared to controls through the first 6 postpartum months, returned to normal levels by 9 months, and remained normal at 12 months. NK cytotoxicity during the first 6 months was further inhibited by the addition of pooled plasma to NK cultures from postpartum women, but the addition of pooled plasma from the control group did not affect that group's NK cultures. There were differences in inhibitory receptor staining between the two groups, with decreased CD158a and CD158b and increased NKG2A expression on postpartum NK cells during the first 3 postpartum months. These data suggest that NK cytotoxicity postpartum inhibition lasts 6 months and is influenced by unidentified postpartum plasma components. The effect may also involve receptors on NK cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.