ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Detection of cytomegalovirus DNA in plasma as an adjunct diagnostic for gastrointestinal tract disease in kidney and liver transplant recipients.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 76 citations in OpenAlex.
- Severe hemorrhage of the colorectum after heart transplantation: a case report.World journal of emergency medicine · 2026Article
- Successful Use of Maribavir for Secondary CMV Prophylaxis in a Pediatric HSCT Patient.Pediatric blood & cancer · 2025Article
- Post-transplant diarrhea in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2025Review
- ICU-acquired infections in immunocompromised patients.Intensive care medicine · 2024Review
- Cytomegalovirus Pneumonia in a Patient with Down Syndrome.Medicina (Kaunas, Lithuania) · 2024Article
- Cytomegalovirus infection in heart transplant patient presenting as appendicitis.Journal of cardiology cases · 2023Article
- Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia.Journal of hematology · 2023Review
- Interleukin-18 and tumor necrosis factor-α are elevated in solid organ transplant recipients with possible cytomegalovirus end-organ disease.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
- Viral infections in inflammatory bowel disease: Tips and tricks for correct management.World journal of gastroenterology · 2021Review
- Post-transplant colitis after kidney transplantation: clinical, endoscopic and histological features.Aging · 2020Article
- Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation.Clinical microbiology reviews · 2020Review
- Gastrointestinal complications after kidney transplantation.World journal of gastroenterology · 2020Review
- Colon perforation due to cytomegalovirus infection in a patient with idiopathic hypereosinophilic syndrome: a case report.BMC gastroenterology · 2020Article
- Clinical Diagnostic Testing for Human Cytomegalovirus Infections.The Journal of infectious diseases · 2020Review
- Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature.World journal of gastroenterology · 2019Review
- Diagnosis and Management of CMV Colitis.Current infectious disease reports · 2019Review
- Accuracy of diagnostic tests and a new algorithm for diagnosing cytomegalovirus colitis in inflammatory bowel diseases: a diagnostic study.International journal of colorectal disease · 2019Article
- Real-time quantitative PCR analysis of endoscopic biopsies for diagnosing CMV gastrointestinal disease in non-HIV immunocompromised patients: a diagnostic accuracy study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Cytomegalovirus Colitis Masquerading as Apple-Core Lesion after Systemic Chemotherapy in a Patient with Relapsed Acute Myeloid Leukemia.Case reports in oncological medicine · 2018Article
- Optimal strategies for the diagnosis of community-onset diarrhea in solid organ transplant recipients: Less is more.Transplant infectious disease : an official journal of the Transplantation Society · 2017Article
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8 authors at 4 institutions in 1 country.
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Abstract
backgroundCytomegalovirus (CMV) disease is the most common infectious complication after solid organ transplantation, frequently affecting the gastrointestinal (GI) tract. There are limited data on quantitative polymerase chain reaction (qPCR) for plasma CMV DNA as an adjunct diagnostic method for GI tract disease in kidney and liver transplant recipients.
methodsWe reviewed all records of adult kidney and liver transplant recipients with a GI tract biopsy and plasma CMV qPCR result within 15 days of biopsy during a 6.5-year period at our center. CMV GI tract disease was defined as histopathologic evidence of CMV on biopsy by immunohistochemistry or visualization of inclusion bodies.
resultsGI tract biopsy and qPCR results were available for 81 kidney and liver transplant recipients; 20 cases of confirmed CMV GI tract disease were identified. Overall, the sensitivity of qPCR for diagnosing CMV GI tract disease was 85% (95% confidence interval [CI], 61%-96%), and the specificity was 95% (95% CI, 85%-99%). For CMV-seronegative recipients (R(-)) with CMV-seropositive donors (D(+)), the sensitivity of qPCR was 100% (95% CI, 59%-99%), and the specificity was 80% (95% CI, 30%-99%). The lowest sensitivity was observed in CMV D(+)/R(+) cases (72.7%; 95% CI, 39%-93%). The mean plasma CMV copy number in patients with GI tract disease was 3.84 log10 (38 334 copies/mL).
conclusionsPlasma CMV qPCR had good sensitivity and excellent specificity for CMV GI tract disease in kidney and liver transplant recipients. Its sensitivity was 100% in CMV D(+)/R(-) cases but 72.7% in CMV D(+)/R(+) cases. This variation in assay performance according to host serostatus may reflect differences in disease pathogenesis.
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