ReviewAlcohol and alcoholism (Oxford, Oxfordshire)
Use of novel technology-based techniques to improve alcohol-related outcomes in clinical trials.
Review in Alcohol and alcoholism (Oxford, Oxfordshire). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Role of the α1 blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial.Addiction biology · 2016Trial
- Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.The Journal of clinical psychiatry · 2015Trial
- Randomized controlled trial of a mobile phone intervention for improving adherence to naltrexone for alcohol use disorders.PloS one · 2015Trial
- What happens when people discontinue taking medications? Lessons from COMBINE.Addiction (Abingdon, England) · 2014Trial
- GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate.Experimental and clinical psychopharmacology · 2014Trial
- Barriers to Alcohol Use Disorder Treatment in Patients with Alcohol-Associated Liver Disease.Clinics in liver disease · 2024Review
- Acceptability and anklet user experience with the SCRAM-CAM transdermal alcohol concentration sensor in regularly drinking young adults' natural environments.Alcohol (Fayetteville, N.Y.) · 2023Article
- Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation.Nature reviews. Gastroenterology & hepatology · 2022Review
- The Clinical Course of Alcohol Use Disorder Depicted by Digital Biomarkers.Frontiers in digital health · 2021Article
- Methods to reduce the incidence of false negative trial results in substance use treatment research.Current opinion in psychology · 2019Review
- Distal Measurements Can Produce False Negative Results: A Prospective Secondary Analysis of a Natural History Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Assessment of Alcohol Use in the Natural Environment.Alcoholism, clinical and experimental research · 2019Review
- Current Advancements in Transdermal Biosensing and Targeted Drug Delivery.Sensors (Basel, Switzerland) · 2019Review
- Combining ecological momentary assessment with objective, ambulatory measures of behavior and physiology in substance-use research.Addictive behaviors · 2018Review
- Recommendations for the Design and Analysis of Treatment Trials for Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2015Review
- High levels of agreement between clinic-based ethyl glucuronide (EtG) immunoassays and laboratory-based mass spectrometry.The American journal of drug and alcohol abuse · 2015Article
- Determining ethyl glucuronide cutoffs when detecting self-reported alcohol use in addiction treatment patients.Alcoholism, clinical and experimental research · 2015Article
- Topiramate for alcoholism treatment: novel pharmacogenetic evidence for the journey to personalized medicine?The international journal of neuropsychopharmacology · 2014Article
- Background for Real-Time Monitoring and Intervention Related to Alcohol Use.Alcohol research : current reviews · 2014Review
- Alcohol consumption and pregnancy in American Indian and Alaska Native women: A scoping review of the literature.Women's health (London, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
With a better understanding of the biologic basis of alcohol dependence and the considerable financial burden of alcohol abuse and dependence, the number of alcohol-related clinical pharmacotherapy trials has been on the rise. Subsequently, the potential to find efficacious treatments is more promising. Unfortunately, alcohol-related trials face a number of challenges, as a result of the difficulties that arise from traditional and outdated methods to collect data and ensure medication adherence. Novel technology-based assessments, such as ecological momentary assessment, interactive voice response, transdermal sensor and medication-event monitoring system provide a prospective solution-albeit not without possible concerns-to the difficulties faced in alcohol-related clinical trials. Clinical trials are meant to define the efficacy of the treatment and to determine an effective and safe dosage. However, due to lack of adherence a drug could inappropriately or mistakenly be judged as ineffective for treating a specific disorder. The described technologies may be important tools to prevent false negatives in validating drug efficacy, to provide consistency in clinical trials and to improve available data regarding the study of pharmacotherapies for alcohol dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.