ArticleNature methods2013
Recombinant antibodies to histone post-translational modifications.
Article in Nature methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Antibody Affinity Maturation by Yeast Mating against a Diverse Antigen Library Enhances Antibody Resistance to Viral Mutations.ACS pharmacology & translational science · 2026Article
- Plant-specific function of H3K9me3 as a permissive chromatin mark during Arabidopsis seed germination.Frontiers in plant science · 2026Article
- Targeted DamID detects cell-type-specific histone modifications in intact tissues or organisms.PLoS biology · 2025Article
- Binding mode-guided development of high-performance antibodies targeting site-specific posttranslational modifications.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia.Journal of molecular biology · 2022Article
- Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity.International journal of molecular sciences · 2022Article
- Engineering Binders with Exceptional Selectivity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A plug and play microfluidic platform for standardized sensitive low-input chromatin immunoprecipitation.Genome research · 2021Article
- Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications.Nature protocols · 2019Article
- HiBiT-qIP, HiBiT-based quantitative immunoprecipitation, facilitates the determination of antibody affinity under immunoprecipitation conditions.Scientific reports · 2019Article
- Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer.Nature communications · 2019Article
- Young genes have distinct gene structure, epigenetic profiles, and transcriptional regulation.Genome research · 2018Article
- Integrating Proteomics and Targeted Metabolomics to Understand Global Changes in Histone Modifications.Proteomics · 2018Review
- Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks.Molecular & cellular proteomics : MCP · 2018Article
- Next-generation antibodies for post-translational modifications.Current opinion in structural biology · 2018Review
- Molecular and functional analysis of monoclonal antibodies in support of biologics development.Protein & cell · 2018Review
- Protein purification and analysis: next generation Western blotting techniques.Expert review of proteomics · 2017Review
- Site selective reading of epigenetic markers by a dual-mode synthetic receptor array.Chemical science · 2017Article
- WERAM: a database of writers, erasers and readers of histone acetylation and methylation in eukaryotes.Nucleic acids research · 2017Article
- Detection of Isoforms Differing by a Single Charge Unit in Individual Cells.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Variability in the quality of antibodies to histone post-translational modifications (PTMs) is a widely recognized hindrance in epigenetics research. Here, we produced recombinant antibodies to the trimethylated lysine residues of histone H3 with high specificity and affinity and no lot-to-lot variation. These recombinant antibodies performed well in common epigenetics applications, and enabled us to identify positive and negative correlations among histone PTMs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.