ArticlePsychopharmacology2014
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03220776 (Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Medial Frontal Cortex GABA Concentrations in Psychosis Spectrum and Mood Disorders: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.Biological psychiatry · 2023Pooled it
- Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies.International journal of molecular sciences · 2022Pooled it
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms.BMC psychiatry · 2016Trial
- Biomarkers of bipolar disorder in omics and neuroimaging.Journal of pharmaceutical analysis · 2025Review
- Metabolic abnormalities in the basal ganglia and cerebellum in bipolar disorder: A multi-modal MR study.Journal of affective disorders · 2022Article
- Insights into myelin dysfunction in schizophrenia and bipolar disorder.World journal of psychiatry · 2022Review
- Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA-PRESS Sequence in Primary Motor Cortex and Occipital Cortex.Journal of magnetic resonance imaging : JMRI · 2022Article
- In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.European archives of psychiatry and clinical neuroscience · 2021Article
- Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.Antioxidants & redox signaling · 2019Review
- Comparing the reproducibility of commonly used magnetic resonance spectroscopy techniques to quantify cerebral glutathione.Journal of magnetic resonance imaging : JMRI · 2019Article
- In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders.European archives of psychiatry and clinical neuroscience · 2018Article
- Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence.Translational psychiatry · 2017Article
- Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study.The international journal of neuropsychopharmacology · 2016Article
- Cortical and subcortical glutathione levels in adults with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2016Article
- GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies.Frontiers in psychiatry · 2016Review
- Neurochemistry of major depression: a study using magnetic resonance spectroscopy.Psychopharmacology · 2015Article
- Hypoactivation of the ventral and dorsal striatum during reward and loss anticipation in antipsychotic and mood stabilizer-naive bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleGlutathione (GSH) is a key scavenger for cellular free radicals, and patients with bipolar disorder may have lowered GSH levels in plasma and in post-mortem brain tissue.
objectivesThe objective of the current study was to use magnetic resonance spectroscopy (MRS) to measure cortical GSH levels in young people with bipolar disorder to determine if lowered GSH might be a useful biomarker of vulnerability to the illness.
methodsWe studied 13 patients with DSM-IV bipolar disorder and 11 healthy age-matched controls using proton MRS in conjunction with the SPECIAL acquisition technique. Voxels were placed in prefrontal and occipital cortex. All patients were clinically euthymic at the time of study and unmedicated. GSH and other relevant neurometabolites were measured relative to creatinine.
resultsThere was no difference in GSH levels between bipolar participants and controls in either prefrontal or occipital cortex. Similarly, participants showed no difference from controls in other measured cortical metabolites including γ-aminobutyric acid, glutamate and N-acetylaspartate.
conclusionsThis pilot study suggests that levels of cortical GSH are unlikely to be a useful trait biomarker of bipolar disorder in young people with a history of relatively mild mood instability at an early stage of illness. Lowered GSH levels may be relevant to bipolar pathophysiology in more severely ill patients, particular those with significant current mood disturbance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.