ArticleAmerican journal of hypertension2014
How many measurements are needed to estimate blood pressure variability without loss of prognostic information?
Article in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- 24-Hour Blood Pressure Variability Assessed by Average Real Variability: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Transauricular Vagus Nerve Stimulation in Acute Ischaemic Stroke Requiring Mechanical Thrombectomy: Sham-Controlled, Randomised Device Trial.Translational stroke research · 2025Trial
- Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Trial
- Effect of dihydropyridine calcium channel blockers on blood pressure variability in the SPRINT trial: a treatment effects approach.Journal of hypertension · 2022Trial
- Blood pressure variability in daily life: comparing individuals with cervical and upper-thoracic spinal cord injury to non-injured controls.Journal of human hypertension · 2026Article
- Associations of Blood Pressure Level and Variability With Cortical Thickness: A Cross-Sectional Analysis From the Maracaibo Aging Study.American journal of hypertension · 2026Article
- Blood pressure dynamic instability and neurodegeneration in older adults.Journal of Alzheimer's disease : JAD · 2025Article
- Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort.American journal of hypertension · 2025Observational
- Blood Pressure Variability (BPV): What Clinicians Need to Know a 2025 Expert Consensus Report Endorsed by the Egyptian Society of Cardiology.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study.Journal of the American Heart Association · 2025Article
- Baseline associations of office and ambulatory blood pressure monitoring with cognitive function and dementia prevalence.Journal of Alzheimer's disease : JAD · 2025Article
- Assessment of blood pressure variability: characteristics and comparison of blood pressure measurement methods.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Reliability of beat-to-beat blood pressure variability in older adults.Scientific reports · 2024Article
- Reliability of beat-to-beat blood pressure variability in older adults.Research square · 2024Article
- Association of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk.American journal of hypertension · 2024Article
- Association of Arterial Stiffness With Mid- to Long-Term Home Blood Pressure Variability in the Electronic Framingham Heart Study: Cohort Study.JMIR cardio · 2024Article
- Regional cerebral oxygen saturation variability and brain injury in preterm infants.Frontiers in pediatrics · 2024Article
- Article
- Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children.Journal of the American Heart Association · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
Abstract
backgroundAverage real variability (ARV) is a recently proposed index for short-term blood pressure (BP) variability. We aimed to determine the minimum number of BP readings required to compute ARV without loss of prognostic information.
methodsARV was calculated from a discovery dataset that included 24-hour ambulatory BP measurements for 1,254 residents (mean age = 56.6 years; 43.5% women) of Copenhagen, Denmark. Concordance between ARV from full (≥80 BP readings) and randomly reduced 24-hour BP recordings was examined, as was prognostic accuracy. A test dataset that included 5,353 subjects (mean age = 54.0 years; 45.6% women) with at least 48 BP measurements from 11 randomly recruited population cohorts was used to validate the results.
resultsIn the discovery dataset, a minimum of 48 BP readings allowed an accurate assessment of the association between cardiovascular risk and ARV. In the test dataset, over 10.2 years (median), 806 participants died (335 cardiovascular deaths, 206 cardiac deaths) and 696 experienced a major fatal or nonfatal cardiovascular event. Standardized multivariable-adjusted hazard ratios (HRs) were computed for associations between outcome and BP variability. Higher diastolic ARV in 24-hour ambulatory BP recordings predicted (P < 0.01) total (HR = 1.12), cardiovascular (HR = 1.19), and cardiac (HR = 1.19) mortality and fatal combined with nonfatal cerebrovascular events (HR = 1.16). Higher systolic ARV in 24-hour ambulatory BP recordings predicted (P < 0.01) total (HR = 1.12), cardiovascular (HR = 1.17), and cardiac (HR = 1.24) mortality.
conclusionsForty-eight BP readings over 24 hours were observed to be adequate to compute ARV without meaningful loss of prognostic information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.