ArticleStem cell reviews and reports2014
Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.
Article in Stem cell reviews and reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Mouflon and Domestic Sheep Phylogeny: Ancestry, Domestication, and Evolutionary Dynamics.Life (Basel, Switzerland) · 2025Review
- Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.Nature communications · 2023Article
- Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle.International journal of medical sciences · 2021Article
- Evolution of the sheep coat: the impact of domestication on its structure and development.Genetics research · 2020Article
- Human epidermal neural crest stem cells as a source of Schwann cells.Development (Cambridge, England) · 2015Article
- Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.Oncotarget · 2015Article
- Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages.Experimental cell research · 2014Review
- Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development.
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Registered trials
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