ArticleJournal of biomedical optics2013
Multiparametric optical coherence tomography imaging of the inner retinal hemodynamic response to visual stimulation.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy.Scientific reports · 2022Article
- Distinguishing cognitive impairment by using singularity spectrum and lacunarity analysis of the retinal vascular network.Neurophotonics · 2019Article
- Investigation of artifacts in retinal and choroidal OCT angiography with a contrast agent.Biomedical optics express · 2018Article
- Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice.Investigative ophthalmology & visual science · 2017Article
- Concurrent OCT imaging of stimulus evoked retinal neural activation and hemodynamic responses.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Photoacoustic imaging of the eye: A mini review.Photoacoustics · 2016Review
- Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers.Biomedical optics express · 2016Article
- Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length.Medical physics · 2015Article
- A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hemodynamic response to neuronal activation is a well-studied phenomenon in the brain, due to the prevalence of functional magnetic resonance imaging. The retina represents an optically accessible platform for studying lamina-specific neurovascular coupling in the central nervous system; however, due to methodological limitations, this has been challenging to date. We demonstrate techniques for the imaging of visual stimulus-evoked hyperemia in the rat inner retina using Doppler optical coherence tomography (OCT) and OCT angiography. Volumetric imaging with three-dimensional motion correction, en face flow calculation, and normalization of dynamic signal to static signal are techniques that reduce spurious changes caused by motion. We anticipate that OCT imaging of retinal functional hyperemia may yield viable biomarkers in diseases, such as diabetic retinopathy, where the neurovascular unit may be impaired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.