ArticleMedical microbiology and immunology2014
ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin expression by targeting the 5' UTR of sarT mRNA.
Article in Medical microbiology and immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 45 citations in OpenAlex.
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- The Small RNA Teg41 Is a Pleiotropic Regulator of Virulence in Staphylococcus aureus.Infection and immunity · 2022Article
- Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus.Scientific reports · 2022Article
- Thirty Years of sRNA-Mediated Regulation inInternational journal of molecular sciences · 2022Review
- RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3'UTR required for intermediate vancomycin resistance.Nature communications · 2022Article
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- Who's in control? Regulation of metabolism and pathogenesis in space and time.Current opinion in microbiology · 2020Review
- Comparative Transcriptomic and Functional Assessments of Linezolid-Responsive Small RNA Genes in Staphylococcus aureus.mSystems · 2020Article
- Regulation ofMicrobiology spectrum · 2019Review
- Noncoding RNA.Microbiology spectrum · 2019Review
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- Bacterial Small RNAs in Mixed Regulatory Networks.Microbiology spectrum · 2018Review
- Small RNA teg49 Is Derived from aInfection and immunity · 2018Article
- sRNA and cis-antisense sRNA identification in Staphylococcus aureus highlights an unusual sRNA gene cluster with one encoding a secreted peptide.Scientific reports · 2017Article
- Insights into the regulation of small RNA expression: SarA represses the expression of two sRNAs in Staphylococcus aureus.Nucleic acids research · 2016Article
- Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1.Medical microbiology and immunology · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies point to the importance of small-noncoding RNAs (sRNAs) in bacterial virulence control. In Staphylococcus aureus, functional dissections of sRNAs are limited to RNA III, SprD, RsaE, SprA1, and SSR42 only. Here, we report the identification and functional analyses of a novel sRNA, which we have designated ArtR. Our data show that the AgrA protein can bind to the artR promoter and repress artR transcription, suggesting that, after RNA III, ArtR is the second sRNA regulated by AgrA. Furthermore, ArtR is unique in S. aureus and involved in virulence regulation by activating α-toxin expression. ArtR promotes the degradation of sarT mRNA by RNase III and arrests the translation of SarT by direct binding to the 5' untranslated region of the sarT mRNA, suggesting that the activation of ArtR on the α-toxin expression was through SarT. This study reveals another kind of staphylococcal regulatory small RNA that plays a role in virulence control. It also indicates the diversity of small RNA-target mRNA interactions and how these multiple interactions can mediate virulence regulation in this pathogen.
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