ArticleNature chemical biology2013
NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin.
Article in Nature chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases.Redox biology · 2024Review
- Construction of a Cosmid-Based Ultraefficient Genomic Library System for Filamentous Fungi of the GenusJournal of fungi (Basel, Switzerland) · 2024Article
- Nitric Oxide in Fungi: Production and Function.Journal of fungi (Basel, Switzerland) · 2024Review
- The Metabolic Regulation of Amino Acid Synthesis Counteracts Reactive Nitrogen Stress viaJournal of fungi (Basel, Switzerland) · 2024Article
- Fungal glyceraldehyde 3-phosphate dehydrogenase GpdC maintains glycolytic mechanism against reactive nitrogen stress-induced damage.Frontiers in microbiology · 2024Article
- Mycothiol maintains the homeostasis and signalling of nitric oxide in Streptomyces coelicolor A3(2) M145.BMC microbiology · 2023Article
- Metallothionein Cup1 attenuates nitrosative stress in the yeastMicrobial cell (Graz, Austria) · 2023Article
- Cytosol Peroxiredoxin and Cell Surface Catalase Differentially Respond to HAntioxidants (Basel, Switzerland) · 2023Article
- Insight into metabolic sensors of nitrosative stress protection inFrontiers in plant science · 2023Article
- Identification and Functional Analysis of GTP Cyclohydrolase II inFrontiers in microbiology · 2022Article
- Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response.Nature communications · 2021Article
- The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus.PLoS genetics · 2019Article
- Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence ofFrontiers in microbiology · 2018Article
- Nitric oxide in fungi: is there NO light at the end of the tunnel?Current genetics · 2016Review
- Anti-Immune Strategies of Pathogenic Fungi.Frontiers in cellular and infection microbiology · 2016Review
- Nitric Oxide in the Offensive Strategy of Fungal and Oomycete Plant Pathogens.Frontiers in plant science · 2016Review
- Nitric oxide synthesis by nitrate reductase is regulated during development in Aspergillus.Molecular microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a toxic reactive nitrogen species that induces microbial adaption mechanisms. Screening a genomic DNA library identified a new gene, ntpA, that conferred growth tolerance upon Aspergillus nidulans against exogenous NO. The gene encoded a cysteine-rich 23-amino-acid peptide that reacted with NO and S-nitrosoglutathione to generate an S-nitrosated peptide. Disrupting ntpA increased amounts of cellular S-nitrosothiol and NO susceptibility. Thioredoxin and its reductase denitrosated the S-nitrosated peptide, decreased cellular S-nitrosothiol and conferred tolerance against NO, indicating peptide-mediated catalytic NO removal. The peptide binds copper(I) in vitro but is dispensable for metal tolerance in vivo. NO but not metal ions induced production of the peptide and ntpA transcripts. We discovered that the thionein family of peptides has NO-related functions and propose that the new peptide be named NO-inducible nitrosothionein (iNT). The ubiquitous distribution of iNT-like polypeptides constitutes a potent NO-detoxifying mechanism that is conserved among various organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.