ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2013
Can flow-volume loops be used to diagnose exercise induced laryngeal obstructions? A comparison study examining the accuracy and inter-rater agreement of flow volume loops as a diagnostic tool.
Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03550456 (Diagnostics of the Quality of Life With Exercise Induced Asthma), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostics of the Quality of Life With Exercise Induced Asthma (EIA) and Exercise Induced Laryngeal Obstruction (EILO)
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Exercise induced laryngeal obstruction: a review of diagnosis and management.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Clinical Case Study: Pediatric Exercise-Induced Laryngeal Obstruction.Perspectives of the ASHA special interest groups · 2025Article
- Exercise-induced bronchoconstriction in children: Delphi study and consensus document about definition and epidemiology, diagnostic work-up, treatment, and follow-up.Respiratory research · 2024Article
- Exercise-Induced Bronchoconstriction in Children: State of the Art from Diagnosis to Treatment.Journal of clinical medicine · 2024Review
- Prevalence and characterisation of exercise-induced laryngeal obstruction in patients with exercise-induced dyspnoea.The Journal of laryngology and otology · 2024Article
- Exercise-induced laryngeal obstruction (EILO) in athletes: a narrative review by a subgroup of the IOC Consensus on 'acute respiratory illness in the athlete'.British journal of sports medicine · 2022Review
- The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.The journal of allergy and clinical immunology. In practice · 2022Article
- High Prevalence of Laryngeal Obstruction during Exercise in Severe Asthma.American journal of respiratory and critical care medicine · 2019Article
- Observational study of laryngoscopy plus flow-volume loops during exercise.Clinical case reports · 2018Article
- Dysfunctional Breathing in Children and Adults With Asthma.Frontiers in pediatrics · 2018Review
- Validity and reliability of grade scoring in the diagnosis of exercise-induced laryngeal obstruction.ERJ open research · 2017Article
- Ergospirometry with concurrent fibre optic laryngoscopy: a randomised crossover study.European clinical respiratory journal · 2017Article
- Differentiating vocal cord dysfunction from asthma.Journal of asthma and allergy · 2017Review
- Exercise-induced laryngeal obstruction: a common and overlooked cause of exertional breathlessness.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016Article
- Larynx during exercise: the unexplored bottleneck of the airways.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Review
- The flow-volume loop in inducible laryngeal obstruction: one component of the complete evaluation.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Article
- Diagnostic utility of spirometry for children with induced laryngeal obstruction or chronic non-specific cough.American journal of otolaryngologyArticle
- Effects of Simulated Altitude on Maximal Oxygen Uptake and Inspiratory Fitness.International journal of exercise scienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre- and post-exercise flow-volume loops are often recommended as an easy non-invasive method for diagnosing or excluding exercise-induced laryngeal obstructions in patients with exercise-related respiratory symptoms. However, at present there is no evidence for this recommendation.
aimsTo compare physician evaluated pre- and post-exercise flow-volume loops and flow data with laryngoscopic findings during exercise.
methodsData from 100 consecutive exercise tests with continuous laryngoscopy during the test were analysed. Laryngoscopic images were compared with the corresponding pre- and post-exercise flow-volume loops assessed by four separate physicians and with data from the loops (forced inspiratory flow (FIF) at 25% vs. FIF at 75% of forced inspiratory vital capacity (FIVC), forced expiratory flow at 50% of forced expiratory volume vs. FIF at 50% of FIVC, and FIVC vs. FIF at 50% of FIVC).
resultsThere was no significant association between the laryngoscopic findings and the flow-volume data. There was no agreement between the four physicians in their assessment of the flow-volume loops (kappa <0.00), and none of the individual physician's assessments were significantly associated with the laryngoscopic findings.
conclusionsExercise-induced laryngeal obstructions cannot be diagnosed or excluded by physician evaluated pre- and post-exercise flow-volume loops or flow data alone.
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