Evidence map›Paper›PMID 23955280›Full record

ArticleHuman vaccines & immunotherapeutics2013

Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine.

D Tien Nguyen, Jolande Boes, Geert van Amerongen, Yvonne van Remmerden, Selma Yüksel, Teun Guichelaar, Albert D M E Osterhaus, Rik L de Swart

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

D Tien NguyenDepartment of Viroscience; Erasmus MC; Rotterdam, The Netherlands.
Jolande BoesNational Institute of Public Health and the Environment; Bilthoven, The Netherlands.
Geert van AmerongenDepartment of Viroscience; Erasmus MC; Rotterdam, The Netherlands; National Institute of Public Health and the Environment; Bilthoven, The Netherlands.
Yvonne van RemmerdenNational Institute of Public Health and the Environment; Bilthoven, The Netherlands.
Selma YükselDepartment of Viroscience; Erasmus MC; Rotterdam, The Netherlands.
Teun GuichelaarNational Institute of Public Health and the Environment; Bilthoven, The Netherlands.
Albert D M E OsterhausDepartment of Viroscience; Erasmus MC; Rotterdam, The Netherlands.
Rik L de SwartDepartment of Viroscience; Erasmus MC; Rotterdam, The Netherlands.
Erasmus University Rotterdam · NLNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of live-attenuated human respiratory syncytial virus (HRSV) vaccines has proven to be difficult. Several vaccine candidates were found to be over-attenuated and displayed limited immunogenicity. Recently, we identified three synthetic cationic lipopeptides that enhanced paramyxovirus infections in vitro. The infection enhancement proved to be mediated by enhanced virus binding to target cells. We hypothesized that these lipopeptides can be used as adjuvants to promote immune responses induced by live-attenuated paramyxovirus vaccines. This hypothesis was tested in a vaccination and challenge model in cotton rats, using a previously described recombinant live-attenuated candidate HRSV vaccine lacking the gene encoding the G glycoprotein (rHRSVΔG). Surprisingly, intranasal vaccination of cotton rats with rHRSVΔG formulated in infection-enhancing lipopeptides resulted in reduced virus loads in nasopharyngeal lavages, reduced seroconversion levels and reduced protection from wild-type HRSV challenge. In conclusion, we were unable to demonstrate the feasibility of lipopeptides as adjuvants for a candidate live-attenuated HRSV vaccine in the cotton rat model.

Indexed as

Adjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, ViralDisease Models, AnimalImmunizationLipopeptidesNasopharynxRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesSigmodontinaeVaccines, AttenuatedViral Envelope ProteinsViral LoadAdjuvants, ImmunologicAntibodies, Viralattachment protein GLipopeptidesRespiratory Syncytial Virus VaccinesVaccines, AttenuatedViral Envelope ProteinsadjuvantHRSVlipopeptidelive-attenuated virus vaccineparamyxovirus

Identifiers

PMID23955280
PMCPMC4162065
OpenAlexW2002748834

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.