Evidence map›Paper›PMID 23955075›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2014

Salivary cortisol and cold pain sensitivity in female twins.

Kathryn M Godfrey, Eric Strachan, Elizabeth Dansie, Leslie J Crofford, Dedra Buchwald, Jack Goldberg, Brian Poeschla, Annemarie Succop, Carolyn Noonan, Niloofar Afari

Abstract readTwin Study
In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Early sympathetic neural responses during a cold pressor test linked to pain perception.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kathryn M GodfreyJoint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA.
Eric Strachan
Elizabeth Dansie
Leslie J Crofford
Dedra Buchwald
Jack Goldberg
Brian Poeschla
Annemarie Succop
Carolyn Noonan
Niloofar Afari
University of Washington · USSan Diego State University · USSeattle Epidemiologic Information and Research Center · USUniversity of California, San Diego · USUniversity of Kentucky · US

Funding

INSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Institute for Translational Health Science (KL2)KL2RR025015 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$9.3M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
Institute for Translational Health Science (TL1)TL1RR025016 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$2.7M
Twin Study of Chronic Widespread PainR01AR051524 · NIAMS · UNIVERSITY OF WASHINGTON · PI AFARI, NILOOFAR · 2005 to 2009
$1.8M
Personality, Stress, and HSV-1 Infection: A Twin StudyR21AI081347 · NIAID · UNIVERSITY OF WASHINGTON · PI STRACHAN, ERIC DANIEL · 2009 to 2010
$343k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1TR000117NCRR NIH HHS KL2 RR025015NCRR NIH HHS KL2RR025015NCRR NIH HHS TL1 RR025016NCRR NIH HHS TL1RR025016NCRR NIH HHS UL1 RR025014NCRR NIH HHS UL1RR025014NCRR NIH HHS UL1 RR033173NCRR NIH HHS UL1RR033173NIAID NIH HHS R21 AI081347NIAID NIH HHS R21AI81347NIAMS NIH HHS R01 AR051524NIAMS NIH HHS R01AR051524NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01DK082325
6 · The paper itself

Abstract

backgroundThere is a dearth of knowledge about the link between cortisol and pain sensitivity. PURPOSE: We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.

methodsThree-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.

resultsLower diurnal variation of cortisol was associated with higher pain ratings at threshold (p = 0.02) and tolerance (p < 0.01). The relationship of diurnal variation with pain ratings at threshold and tolerance was minimally influenced by familial factors (i.e., genetics and common environment).

conclusionsUnderstanding the genetic and non-genetic mechanisms underlying the link between HPA axis dysregulation and pain sensitivity may help to prevent chronic pain development and maintenance.

Indexed as

TwinsAdolescentAdultCold TemperatureFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemPainPain MeasurementPain ThresholdPituitary-Adrenal SystemSalivaYoung AdultHydrocortisone

Identifiers

PMID23955075
PMCPMC3926904
OpenAlexW2043259039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.