Evidence map›Paper›PMID 23954849›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model.

Ofra Ben-Menachem-Zidon, Ofra Ben Menachem-Zidon, Yair Ben-Menahem, Tamir Ben-Hur, Raz Yirmiya

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Modulation of adult hippocampal neurogenesis by interleukin 1 signaling.Neurobiology of sleep and circadian rhythms · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Fatty Acid-DerivedNutrients · 2022
    Article
  9. Review
  10. Review
  11. Modulation of Neural Networks by Interleukin-1.Brain plasticity (Amsterdam, Netherlands) · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. [Protective effect of butylphthalide in a cell model of Alzheimer's disease induced by Aβ25-35 in Neuro 2a cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017
    Article
  17. Review
  18. Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ofra Ben-Menachem-Zidon
Ofra Ben Menachem-ZidonDepartment of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.
Yair Ben-MenahemDepartment of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.
Tamir Ben-HurDepartment of Neurology, Hadassah-Hebrew University Hospital, Jerusalem, Israel.
Raz YirmiyaDepartment of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ample evidence implicates neuroinflammatory processes in the etiology and progression of Alzheimer's disease (AD). To assess the specific role of the pro-inflammatory cytokine interleukin-1 (IL-1) in AD we examined the effects of intra-hippocampal transplantation of neural precursor cells (NPCs) with transgenic over-expression of IL-1 receptor antagonist (IL-1raTG) on memory functioning and neurogenesis in a murine model of AD (Tg2576 mice). WT NPCs- or sham-transplanted Tg2576 mice, as well as naive Tg2576 and WT mice served as controls. To assess the net effect of IL-1 blockade (not in the context of NPCs transplantation), we also examined the effects of chronic (4 weeks) intra-cerebroventricular (i.c.v.) administration of IL-1ra. We report that 12-month-old Tg2576 mice exhibited increased mRNA expression of hippocampal IL-1β, along with severe disturbances in hippocampal-dependent contextual and spatial memory as well as in neurogenesis. Transplantation of IL-1raTG NPCs 1 month before the neurobehavioral testing completely rescued these disturbances and significantly increased the number of endogenous hippocampal cells expressing the plasticity-related molecule BDNF. Similar, but less-robust effects were also produced by transplantation of WT NPCs and by i.c.v. IL-1ra administration. NPCs transplantation produced alterations in hippocampal plaque formation and microglial status, which were not clearly correlated with the cognitive effects of this procedure. The results indicate that elevated levels of hippocampal IL-1 are causally related to some AD-associated memory disturbances, and provide the first example for the potential use of genetically manipulated NPCs with anti-inflammatory properties in the treatment of AD.

Indexed as

Disease Models, AnimalAlzheimer DiseaseAnimalsGene Expression RegulationHippocampusInterleukin 1 Receptor Antagonist ProteinMaleMemoryMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicNeural Stem CellsNeurogenesisNeuronsIl1rn protein, mouseInterleukin 1 Receptor Antagonist Protein

Identifiers

PMID23954849
PMCPMC3870779
OpenAlexW2056989352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.