Evidence map›Paper›PMID 23954844›Full record

ReviewNeurochemistry international2013

All's well that transcribes well: non-coding RNAs and post-stroke brain damage.

Raghu Vemuganti

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Neurochemistry international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04382963 (Stroke Prevention in the Wisconsin Native American Population), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04382963 nacompletednot on this mapstarted 2021, after this paper: background citation

Stroke Prevention in the Wisconsin Native American Population

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2021 to 2025Enrolled120ConditionsStroke, AtherosclerosisArmsHigh Risk - intensive coaching, High Risk - standard care, Low Risk - control
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  15. The elevation of S100B and downregulation of circulating miR-602 in the sera of ischemic stroke (IS) patients: the emergence of novel diagnostic and prognostic markers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Raghu VemugantiDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA. Electronic address: Vemuganti@neurosurgery.wisc.edu.
University of Wisconsin–Madison · US

Funding

Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
PiRNAs and ischemic brain damageR21NS074444 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2011 to 2012
$408k
miRNAs and PPAR-gamma-induced neuroprotectionR21NS079585 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2012 to 2013
$406k
Role of MicroRNAs in stroke-induced brain damage and protectionR21NS061071 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2008 to 2009
$354k
NINDS NIH HHS NS074444NINDS NIH HHS NS079585NINDS NIH HHS R01 NS064034NINDS NIH HHS R21 NS061071NINDS NIH HHS R21 NS074444NINDS NIH HHS R21 NS079585
6 · The paper itself

Abstract

The mammalian genome is replete with various classes of non-coding (nc) RNA genes. Many of them actively transcribe, and their relevance to CNS diseases is just beginning to be understood. CNS is one of the organs in the body that shows very high ncRNAs activity. Recent studies demonstrated that cerebral ischemia rapidly changes the expression profiles of different classes of ncRNAs: including microRNA, long noncoding RNA and piwi-interacting RNA. Several studies further showed that post-ischemic neuronal death and/or plasticity/regeneration can be altered by modulating specific microRNAs. These studies are of interest for therapeutic development as they may contribute to identifying new ncRNA targets that can be modulated to prevent secondary brain damage after stroke.

Indexed as

Transcription, GeneticAnimalsHumansRNA, UntranslatedStrokeRNA, UntranslatedCerebral ischemiamicroRNAMolecular mechanismsPathophysiologyTranscriptionTranslation

Identifiers

PMID23954844
PMCPMC3805745
OpenAlexW1982373471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.