ReviewOsteoarthritis and cartilage2013
Articular osteochondrosis: a comparison of naturally-occurring human and animal disease.
Review in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 108 citations in OpenAlex.
- Sitting foot: posture dependent changes of volume, edema and perfusion of the foot. A prospective interventional study with 27 volunteers.BMC musculoskeletal disorders · 2024Trial
- Quantitative traits of early-stage osteochondrosis lesions in porcine distal femurs are consistent with skeletal developmental age.JBMR plus · 2026Article
- Management and Outcomes of Osteochondritis Dissecans of the Knee in the Pediatric and Adolescent Population.Current reviews in musculoskeletal medicine · 2026Review
- Natural progression of tarsal osteochondrosis in Standardbred pacers and trotters.Veterinary surgery : VS · 2026Article
- [Osteonecrosis and osteochondrosis : Clinical introduction].Radiologie (Heidelberg, Germany) · 2026Review
- Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Juvenile Osteochondritis Dissecans: A Case Report.Diagnostics (Basel, Switzerland) · 2024Article
- Predicted genetic burden and frequency of phenotype-associated variants in the horse.Scientific reports · 2024Article
- Relationship between the extent of vascular injury and the evolution of surgically induced osteochondrosis lesions in a piglet model.PloS one · 2024Article
- Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals.eLife · 2023Article
- Republication of "Osteochondral Lesions of the Talus: Current Concepts in Diagnosis and Treatment".Foot & ankle orthopaedics · 2023Review
- Naturally occurring osteochondrosis latens lesions identified by quantitative and morphological 10.5 T MRI in pigs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Plantar osteochondral fragments in young Standardbreds are associated with minimal joint inflammation at the time of surgical removal.Equine veterinary journal · 2023Article
- Tissue Engineering of Canine Cartilage from Surgically Debrided Osteochondritis Dissecans Fragments.Annals of biomedical engineering · 2022Article
- Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.PLoS genetics · 2021Article
- Radiographic diagnosis and surgical management for successful outcomes for osteochondrosis in Japanese Black calves.The Journal of veterinary medical science · 2021Article
- Three-dimensional-printed custom guides for bipolar coxofemoral osteochondral allograft in dogs.PloS one · 2021Article
- Genetic Variation and the Distribution of Variant Types in the Horse.Frontiers in genetics · 2021Article
- MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T.Osteoarthritis and cartilage · 2020Article
- Roca disease: An osteochondrosis of the inferior pole of the scapula with review of the literature.Radiology case reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundOsteochondrosis (OC) is a common developmental orthopedic disease affecting both humans and animals. Despite increasing recognition of this disease among children and adolescents, its pathogenesis is incompletely understood because clinical signs are often not apparent until lesions have progressed to end-stage, and examination of cadaveric early lesions is not feasible. In contrast, both naturally-occurring and surgically-induced animal models of disease have been extensively studied, most notably in horses and swine, species in which OC is recognized to have profound health and economic implications. The potential for a translational model of human OC has not been recognized in the existing human literature.
objectiveThe purpose of this review is to highlight the similarities in signalment, predilection sites and clinical presentation of naturally-occurring OC in humans and animals and to propose a common pathogenesis for this condition across species. STUDY
designReview.
methodsThe published human and veterinary literature for the various manifestations of OC was reviewed. Peer-reviewed original scientific articles and species-specific review articles accessible in PubMed (US National Library of Medicine) were eligible for inclusion.
resultsA broad range of similarities exists between OC affecting humans and animals, including predilection sites, clinical presentation, radiographic/MRI changes, and histological appearance of the end-stage lesion, suggesting a shared pathogenesis across species.
conclusionThis proposed shared pathogenesis for OC between species implies that naturally-occurring and surgically-induced models of OC in animals may be useful in determining risk factors and for testing new diagnostic and therapeutic interventions that can be used in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.