Trial reportPain2013
Emotional modulation of pain and spinal nociception in persons with major depressive disorder (MDD).
Trial report in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Understanding Monitoring Technologies for Adults With Pain: Systematic Literature Review.Journal of medical Internet research · 2017Pooled it
- Modulation of pain by affective touch: effects of childhood trauma, depression, chronic pain, and spinal segment.The Journal of physiology · 2026Article
- Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain.Frontiers in psychiatry · 2026Article
- Article
- Opioid Receptor Mu 1 Gene (OPRM1) A118G Polymorphism and Emotional Modulation of Pain.Journal of pain research · 2024Article
- Affective and social pain modulation in children-Experimental evidence using picture viewing.PloS one · 2024Article
- A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective disturbance on pain in older adults: A protocol for the sleep and Healthy Aging Research for pain (SHARE-P) study.Brain, behavior, & immunity - health · 2023Article
- Sleep Quality Mediates the Effect of Sensitization-Associated Symptoms, Anxiety, and Depression on Quality of Life in Individuals with Post-COVID-19 Pain.Brain sciences · 2022Article
- Spinal pain and major depression in a military cohort: bias analysis of dependent misclassification in electronic medical records.Social psychiatry and psychiatric epidemiology · 2022Article
- Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review.Sensors (Basel, Switzerland) · 2020Review
- Conditioned Pain Modulation in Sexual Assault Survivors.The journal of pain · 2019Article
- Race/Ethnicity Does Not Moderate the Relationship Between Adverse Life Experiences and Temporal Summation of the Nociceptive Flexion Reflex and Pain: Results From the Oklahoma Study of Native American Pain Risk.The journal of pain · 2019Article
- Impairment of Inhibition of Trigeminal Nociception via Conditioned Pain Modulation in Persons with Migraine Headaches.Pain medicine (Malden, Mass.) · 2019Article
- Latent variable analysis of negative affect and its contributions to neural responses during shock anticipation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Sleep disturbances in tension-type headache and migraine.Therapeutic advances in neurological disorders · 2018Review
- Variables associated with sleep quality in chronic tension-type headache: A cross-sectional and longitudinal design.PloS one · 2018Article
- The burden of headache is associated to pain interference, depression and headache duration in chronic tension type headache: a 1-year longitudinal study.The journal of headache and pain · 2017Article
- The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache.The journal of headache and pain · 2017Article
- Sufficient explanation of management affects patient satisfaction and the practice of post-treatment management in spinal pain, a multicenter study of 1007 patients.The Korean journal of pain · 2017Article
- Endogenous inhibition of pain and spinal nociception in women with premenstrual dysphoric disorder.Journal of pain research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD) is associated with risk for chronic pain, but the mechanisms contributing to the MDD and pain relationship are unclear. To examine whether disrupted emotional modulation of pain might contribute, this study assessed emotional processing and emotional modulation of pain in healthy controls and unmedicated persons with MDD (14 MDD, 14 controls). Emotionally charged pictures (erotica, neutral, mutilation) were presented in 4 blocks. Two blocks assessed physiological-emotional reactions (pleasure/arousal ratings, corrugator electromyography (EMG), startle modulation, skin conductance) in the absence of pain and 2 blocks assessed emotional modulation of pain and the nociceptive flexion reflex (NFR, a physiological measure of spinal nociception) evoked by suprathreshold electric stimulations. Results indicated pictures generally evoked the intended emotional responses; erotic pictures elicited pleasure, subjective arousal, and smaller startle magnitudes, whereas mutilation pictures elicited displeasure, corrugator EMG activation, and subjective/physiological arousal. However, emotional processing was partially disrupted in MDD, as evidenced by a blunted pleasure response to erotica and a failure to modulate startle according to a valence linear trend. Furthermore, emotional modulation of pain was observed in controls but not MDD, even though there were no group differences in NFR threshold or emotional modulation of NFR. Together, these results suggest supraspinal processes associated with emotion processing and emotional modulation of pain may be disrupted in MDD, but brain to spinal cord processes that modulate spinal nociception are intact. Thus, emotional modulation of pain deficits may be a phenotypic marker for future pain risk in MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.