ArticleBrain research2013
DNA methylation markers in the postnatal developing rat brain.
Article in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivity.bioRxiv : the preprint server for biology · 2025Article
- Review
- Epigenetic regulation of iron metabolism and ferroptosis in Parkinson's disease: Identifying novel epigenetic targets.Acta pharmacologica Sinica · 2025Review
- Nurture outpaces nature: fostering with an attentive mother alters social dominance in a mouse model of stress sensitivity.Molecular psychiatry · 2023Article
- Role of DNMTs in the Brain.Advances in experimental medicine and biology · 2022Review
- No Effects of Photobiomodulation on Prefrontal Cortex and Hippocampal Cytochrome C Oxidase Activity and Expression of c-Fos Protein of Young Male and Female Rats.Frontiers in neuroscience · 2022Article
- Accelerated epigenetic aging in adolescents from low-income households is associated with altered development of brain structures.Metabolic brain disease · 2020Article
- Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- DNA Methyltransferases in Depression: An Update.Frontiers in psychiatry · 2020Review
- Dynamic changes in DNA methylation during embryonic and postnatal development of an altricial wild bird.Ecology and evolution · 2019Article
- DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.Clinical epigenetics · 2019Article
- Global DNA Methylation in the Limbic System of Cattle.Epigenomes · 2019Article
- Altered DNA Methylation in the Developing Brains of Rats Genetically Prone to High versus Low Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Epigenetic modulation during hippocampal development.Biomedical reports · 2018Review
- Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewal.Scientific reports · 2018Article
- Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A.Oncology letters · 2018Article
- Evaluation of Post-Mortem Effects on Global Brain DNA Methylation and Hydroxymethylation.Basic & clinical pharmacology & toxicology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In spite of intense interest in how altered epigenetic processes including DNA methylation may contribute to psychiatric and neurodevelopmental disorders, there is a limited understanding of how methylation processes change during early postnatal brain development. The present study used in situ hybridization to assess mRNA expression for the three major DNA methyltranserases (DNMTs)--DNMT1, DNMT3a and DNMT3b--in the developing rat brain at seven developmental timepoints: postnatal days (P) 1, 4, 7, 10, 14, 21, and 75. We also assessed 5-methylcytosine levels (an indicator of global DNA methylation) in selected brain regions during the first three postnatal weeks. DNMT1, DNMT3a and DNMT3b mRNAs are widely expressed throughout the adult and postnatal developing rat brain. Overall, DNMT mRNA levels reached their highest point in the first week of life and gradually decreased over the first three postnatal weeks within the hippocampus, amygdala, striatum, cingulate and lateral septum. Global DNA methylation levels did not follow this developmental pattern; methylation levels gradually increased over the first three postnatal weeks in the hippocampus, and remained stable in the developing amygdala and prefrontal cortex. Our results contribute to a growing understanding of how DNA methylation markers unfold in the developing brain, and highlight how these developmental processes may differ within distinct brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.