ArticleNeuropharmacology2014
Trajectory of adolescent cannabis use on addiction vulnerability.
Article in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- The relationship between childhood trauma and internet addiction in adolescents: A meta-analysis.Journal of behavioral addictions · 2024Pooled it
- Cannabis Use in Adults Who Screen Positive for Attention Deficit/Hyperactivity Disorder: CANreduce 2.0 Randomized Controlled Trial Subgroup Analysis.Journal of medical Internet research · 2022Trial
- Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood.PloS one · 2016Trial
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- ADHD Symptoms and Cannabis Use: The Role of Cannabinoid Receptor 1 and Neural Response Inhibition.medRxiv : the preprint server for health sciences · 2026Article
- Memory impairment and chronic high-dose Δ9-THC/cannabis exposure: a narrative review of molecular mechanisms underlying neurotoxic effects.Psychopharmacology · 2026Review
- Three-day delta-9-tetrahydrocannabinol (THC) exposure eliminates long-term depression in ventral tegmental area of young, but not adult mice.Journal of cannabis research · 2025Article
- The Developmental Trajectory to Cannabis Use Disorder.The American journal of psychiatry · 2024Article
- The Impact of Problematic Internet Use on Adolescent Loneliness-Chain Mediation Effects of Social Support and Family Communication.Psychology research and behavior management · 2024Article
- Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring.Molecular and cellular neurosciences · 2023Article
- Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The Influence of Childhood Trauma and Family Functioning on Internet Addiction in Adolescents: A Chain-Mediated Model Analysis.International journal of environmental research and public health · 2022Article
- Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice.Psychopharmacology · 2022Article
- Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress.Psychopharmacology · 2022Article
- Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice.Psychopharmacology · 2021Article
- Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates.British journal of pharmacology · 2021Article
- Race/ethnicity differences in risk and protective factors for marijuana use among U.S. adolescents.BMC public health · 2021Article
- Adolescent cannabis and tobacco use are associated with opioid use in young adulthood-12-year longitudinal study in an urban cohort.Addiction (Abingdon, England) · 2021Article
- The prospective association between illicit drug use and nonprescription opioid use among vulnerable adolescents.Preventive medicine · 2021Article
- Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping.Frontiers in psychology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The adolescent brain is a period of dynamic development making it vulnerable to environmental factors such as drug exposure. Of the illicit drugs, cannabis is most used by teenagers since it is perceived by many to be of little harm. This perception has led to a growing number of states approving its legalization and increased accessibility. Most of the debates and ensuing policies regarding cannabis were done without consideration of its impact on one of the most vulnerable population, namely teens, or without consideration of scientific data. We provide an overview of the endocannabinoid system in relation to adolescent cannabis exposure and provide insights regarding factors such as genetics and behavioral traits that confer risk for subsequent addiction. While it is clear that more systematic scientific studies are needed to understand the long-term impact of adolescent cannabis exposure on brain and behavior, the current evidence suggests that it has a far-reaching influence on adult addictive behaviors particularly for certain subsets of vulnerable individuals. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.