ArticleCell2013
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
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Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
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94citing papers in PubMed, 2 pooled it
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94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
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- The emerging role of autophagy in the rewarding and stimulant behaviors in models of substance use disorder.Frontiers in neuroscience · 2026Review
- The Biological Role and Clinical Significance of BECLIN-1 in Cancer.International journal of molecular sciences · 2025Review
- FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter.Endocrinology · 2025Article
- Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach.ACS omega · 2025Article
- Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer.Oncology research · 2025Article
- ZMAT2 condensates regulate the alternative splicing of TRIM28 to reduce cellular ROS accumulation, thereby promoting the proliferation of HCC cells.Cell communication and signaling : CCS · 2024Article
- The nonautophagic functions of autophagy-related proteins.Autophagy · 2024Review
- Sesamin-mediated high expression ofAging · 2024Article
- The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.Autophagy · 2023Article
- Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.Science signaling · 2023Article
- Insights into nanoparticles-induced neurotoxicity and cope up strategies.Frontiers in neuroscience · 2023Review
34 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 6 institutions in 2 countries.
Congcong HeHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yongjie WeiHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kai SunTouchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Binghua LiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xiaonan DongCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Zhongju ZouHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yang LiuCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lisa N KinchHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Shaheen KhanDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sangita SinhaDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58102, USA.
Ramnik J XavierCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Nick V GrishinHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Guanghua XiaoDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Eeva-Liisa EskelinenDepartment of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, FI-00014 Finland.
Philipp E SchererTouchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jennifer L WhistlerErnest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA.
Beth LevineHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: beth.levine@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · USMassachusetts General Hospital · USNorth Dakota State University · USUniversity of California, San Francisco · USUniversity of Helsinki · FI
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTARGETING AND DELIVERYP20RR015566 · NCRR · NORTH DAKOTA STATE UNIVERSITY · PI DORSAM, GLENN PAUL · 2001 to 2011
$19.0MNovel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K. · 2010 to 2019
$17.4MAdiponectin, A Protein Secreted From Adipose TissueR01DK055758 · NIDDK · YESHIVA UNIVERSITY · PI SCHERER, PHILIPP E · 2000 to 2024
$10.9MPilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9MBeclin 1-Bcl-2 Interactions: Effects on AutophagyR01CA109618 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BETH C · 2004 to 2014
$3.1MComputational methods for structural-functional studies of proteinsR01GM094575 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GRISHIN, NICK V. · 2010 to 2017
$2.4MRole of opioid receptor trafficking in tolerance and dependenceR01DA019958 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WHISTLER, JENNIFER L · 2007 to 2011
$1.8MMolecular mechanism by which gamma-herpesviruses evade autophagyR21AI078108 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SINHA, SANGITA · 2008 to 2009
$415kA novel autophagy gene beclin 2 in the prevention of type 2 diabetes and obesityK99DK094980 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HE, CONGCONG · 2012 to 2013
$180kNCI NIH HHS R01 CA109618NCI NIH HHS R0I CA109618NCRR NIH HHS P20 RR015566NIAID NIH HHS R21 AI078108NIAID NIH HHS R21 AI078198NIDA NIH HHS R01 DA019958NIDA NIH HHS R0I DA019958NIDDK NIH HHS K99 DK094980NIDDK NIH HHS P01 DK088761NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK055758NIDDK NIH HHS R0I DK043351NIDDK NIH HHS R0I DK55758NIGMS NIH HHS P30 GM103332NIGMS NIH HHS R01 GM094575NIGMS NIH HHS R0I GM094575
Abstract
The molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways remain incompletely understood. Here, we identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. However, Beclin 2, but not Beclin 1, functions in an additional lysosomal degradation pathway. Beclin 2 is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (GPCRs) through its interaction with GASP1. Beclin 2 homozygous knockout mice have decreased embryonic viability, and heterozygous knockout mice have defective autophagy, increased levels of brain cannabinoid 1 receptor, elevated food intake, and obesity and insulin resistance. Our findings identify Beclin 2 as a converging regulator of autophagy and GPCR turnover and highlight the functional and mechanistic diversity of Beclin family members in autophagy, endolysosomal trafficking, and metabolism.
Indexed as
AutophagyAmino Acid SequenceAnimalsApoptosis Regulatory ProteinsBeclin-1HumansIntracellular Signaling Peptides and ProteinsLysosomesMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataObesityReceptors, G-Protein-CoupledApoptosis Regulatory ProteinsBeclin-1BECN1 protein, humanBecn1 protein, mouseBECN2 protein, humanBecn2 protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, G-Protein-Coupled
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