Evidence map›Paper›PMID 23954042›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014

Impact of offspring death on cognitive health in late life: the Cache County study.

Daylee Greene, JoAnn T Tschanz, Ken R Smith, Truls Ostbye, Chris Corcoran, Kathleen A Welsh-Bohmer, Maria C Norton, Cache County Investigators

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Death of a Child Prior to Midlife, Dementia Risk, and Racial Disparities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Daylee GreeneDepartment of Family Consumer and Human Development, Utah State University, Logan, UT.
JoAnn T TschanzDepartment of Psychology, Center for Epidemiologic Studies, Utah State University, Logan, UT.
Ken R SmithDepartment of Family and Consumer Studies, Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.
Truls OstbyeDuke Global Health Institute, Duke University, Durham, NC; Duke-NUS Graduate Medical School, Singapore.
Chris CorcoranDepartment of Mathematics and Statistics, Center for Epidemiologic Studies, Utah State University, Logan, UT.
Kathleen A Welsh-BohmerThe Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC.
Maria C NortonDepartment of Family Consumer and Human Development, Utah State University, Logan, UT; Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan, UT. Electronic address: maria.norton@usu.edu.
Cache County Investigators
Utah State University · USDuke-NUS Medical School · SGDuke University · USHuntsman Cancer Institute · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
EPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAHR01AG011380 · NIA · JOHNS HOPKINS UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 1994 to 2009
$12.2M
The Utah Study of Fertility, Longevity and AgingR01AG022095 · NIA · UNIVERSITY OF UTAH · PI SMITH, KEN R · 2003 to 2015
$9.4M
Lifespan Stressors and Alzheimer's Disease: The Cache County StudyR01AG031272 · NIA · UTAH STATE UNIVERSITY · PI NORTON, MARIA C · 2008 to 2010
$967k
NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA42014NIA NIH HHS AG-022095NIA NIH HHS R01 AG011380NIA NIH HHS R01-AG011380NIA NIH HHS R01 AG022095NIA NIH HHS R01 AG031272NIA NIH HHS R01-AG031272
6 · The paper itself

Abstract

objectiveExperiencing the death of a child is associated with negative short-term mental health consequences, but less is known about cognitive outcomes and whether such associations extend to late life. We tested the hypothesis that experiencing an offspring death (OD) is associated with an increased rate of cognitive decline in late life.

methodsThis population-based longitudinal study observed four cognitive statuses spaced 3-4 years apart, linked to an extensive database containing objective genealogic and vital statistics data. Home visits were conducted with 3,174 residents of a rural county in northern Utah, initially without dementia, aged 65-105. Cognitive status was measured with the Modified Mini-Mental State Exam at baseline and at 3-, 7-, and 10-year follow-ups. OD was obtained from the Utah Population Database, which contains statewide birth and death records.

resultsIn linear mixed models, controlling for age, gender, education, and apolipoprotein E status, subjects who experienced OD while younger than age 31 years experienced a significantly faster rate of cognitive decline in late life, but only if they had an ε4 allele. Reclassifying all OD (regardless of age) according to subsequent birth of another child, OD was only related to faster cognitive decline when there were no subsequent births.

conclusionExperiencing OD in early adulthood has a long-term association with cognitive functioning in late life, with a gene-environment interaction at the apolipoprotein E locus. Subsequent birth of another child attenuates this association.

Indexed as

Life Change EventsParent-Child RelationsAdolescentAdultAgedAged, 80 and overAge FactorsApolipoprotein E4Cognition DisordersFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsSex FactorsApolipoprotein E4apoECognitive declinepsychosocial stress

Identifiers

PMID23954042
PMCPMC3923854
OpenAlexW1964690551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.