Evidence map›Paper›PMID 23953802›Full record

ReviewSeminars in nephrology2013

Gut sensing of potassium intake and its role in potassium homeostasis.

Jang H Youn

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026
    Review
  2. Quantitative analysis of skeletal muscle contributions to ECF KAmerican journal of physiology. Cell physiology · 2026
    Review
  3. How Does Dietary Potassium Influence BP?Journal of the American Society of Nephrology : JASN · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Plant-Based Diets across the Spectrum of Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Directing two-way traffic in the kidney: A tale of two ions.The Journal of general physiology · 2022
    Article
  13. Article
  14. Potassium homeostasis: sensors, mediators, and targets.Pflugers Archiv : European journal of physiology · 2022
    Review
  15. Article
  16. Hyperkalemia in Chronic Kidney Disease: Links, Risks and Management.International journal of nephrology and renovascular disease · 2022
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jang H YounDepartment of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9142, USA. youn@usc.edu

Funding

Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the BrainR21DK090749 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YOUN, JANG H. · 2011 to 2012
$446k
NIDDK NIH HHS DK090749NIDDK NIH HHS R21 DK090749
6 · The paper itself

Abstract

Extracellular K(+) homeostasis has been explained by feedback mechanisms in which changes in extracellular K(+) concentration drive renal K(+) excretion directly or indirectly via stimulating aldosterone secretion. However, this cannot explain meal-induced kaliuresis, which often occurs without increases in plasma K(+) or aldosterone concentrations. Recent studies have produced evidence supporting a feedforward control in which gut sensing of dietary K(+) increases renal K(+) excretion (and extrarenal K(+) uptake) independent of plasma K(+) concentrations, namely, a gut factor. This review focuses on these new findings and discusses the role of gut factor in acute and chronic regulation of extracellular K(+) as well as in the beneficial effects of high K(+) intake on the cardiovascular system.

Indexed as

AnimalsGastrointestinal HormonesHomeostasisHumansInsulinPotassiumPotassium, DietaryGastrointestinal HormonesInsulinPotassiumPotassium, Dietaryfeedback controlfeedforward controlpotassium adaptationpotassium balancePotassium excretion

Identifiers

PMID23953802
PMCPMC3748407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.