ReviewDental materials : official publication of the Academy of Dental Materials2013
Strategies to prevent hydrolytic degradation of the hybrid layer-A review.
Review in Dental materials : official publication of the Academy of Dental Materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 8 syntheses or guidelines pooled it, 405 citations in OpenAlex.
- Comparison of universal adhesives used in different etching modes on dentin bond strength: a systematic review and network meta-analysis.BMC oral health · 2026Pooled it
- Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.Odontology · 2025Pooled it
- Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and meta-analysis of randomized clinical trials.Scientific reports · 2022Pooled it
- Pooled it
- Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review.Scientific reports · 2022Pooled it
- Effect of 2% Chlorhexidine Following Acid Etching on Microtensile Bond Strength of Resin Restorations: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- Clinical performance of the ethanol-wet bonding technique with different adhesive systems in noncarious cervical lesion restorations: a 6-year randomized clinical trial.Clinical oral investigations · 2026Trial
- Clinical Performance of a "No Wait" Universal Adhesive in Noncarious Cervical Lesions: A Two-year Randomized Controlled Clinical Trial.The journal of adhesive dentistry · 2022Trial
- From bioactivity to biofunctional restorative materials: reappraising terminology and evidence.Clinical oral investigations · 2026Review
- Influence of Air-Abrasion Pretreatments and Adhesive Composition on Bond Durability to Natural Sclerotic Dentin.Dentistry journal · 2026Article
- Effect of Bond Strength of Chitosan Containing Cavity Disinfectant on Deep or Superficial Dentin.Biomimetics (Basel, Switzerland) · 2026Article
- Antioxidant, Antibacterial, and Dental Bond Strength Performance ofMolecules (Basel, Switzerland) · 2026Article
- Preparation and Structural Evolution of ZrBMaterials (Basel, Switzerland) · 2026Article
- Commercial trends in universal adhesive evolution: updated formulations do not consistently improve dentin bond strength after aging compared with predecessors and a multistep reference.BMC oral health · 2026Article
- The Role of Matrix Metalloproteinases in Orthodontics, Dental Trauma, Restorative Dentistry, and Endodontics: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Immediate dentin sealing: current concepts, clinical workflow, and evidence-based applications.The Saudi dental journal · 2026Review
- The application of cold atmospheric plasma on human dentin improves its bond strength capacities: an in vitro study.Odontology · 2026Article
- Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins.Biomaterials · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 6 countries.
Funding
Abstract
objectiveEndogenous dentin collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, are responsible for the time-dependent hydrolysis of collagen matrix of hybrid layers. As collagen matrix integrity is essential for the preservation of long-term dentin bond strength, inhibition of endogenous dentin proteases is necessary for durable resin-bonded restorations.
methodsSeveral tentative approaches to prevent enzyme function have been proposed. Some of them have already demonstrated clinical efficacy, while others need to be researched further before clinical protocols can be proposed. This review will examine both the principles and outcomes of techniques to prevent collagen hydrolysis in dentin-resin interfaces.
resultsChlorhexidine, a general inhibitor of MMPs and cysteine cathepsins, is the most tested method. In general, these experiments have shown that enzyme inhibition is a promising approach to improve hybrid layer preservation and bond strength durability. Other enzyme inhibitors, e.g. enzyme-inhibiting monomers, may be considered promising alternatives that would allow more simple clinical application than chlorhexidine. Cross-linking collagen and/or dentin matrix-bound enzymes could render hybrid layer organic matrices resistant to degradation. Alternatively, complete removal of water from the hybrid layer with ethanol wet bonding or biomimetic remineralization should eliminate hydrolysis of both collagen and resin components. SIGNIFICANCE: Understanding the function of the enzymes responsible for the hydrolysis of hybrid layer collagen has prompted several innovative approaches to retain hybrid layer integrity and strong dentin bonding. The ultimate goal, prevention of collagen matrix degradation with clinically applicable techniques and commercially available materials may be achievable in several ways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.