ArticleThe American journal on addictions
Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers.
Article in The American journal on addictions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Assessing changes in sleep across four weeks among adolescents randomized to incentivized cannabis abstinence.Drug and alcohol dependence · 2023Trial
- Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health.Psychopharmacology · 2026Article
- Considering Substance Use in Dysfunctional Beliefs About Sleep: Validation of the DBAS-S.Behavioral sleep medicine · 2026Article
- Sleep Motives and Expectancies for Cannabis Use in Pregnancy.Cannabis (Albuquerque, N.M.) · 2026Article
- Sleep quality and duration following the use and co-use of alcohol and cannabis in the daily life of community adults.Drug and alcohol dependence · 2025Article
- Sleep quality and duration as predictors of alcohol and cannabis use motives in daily life.Addictive behaviors · 2025Article
- UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Epilepsy.Brain and behavior · 2025Observational
- UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia.PLOS mental health · 2025Article
- Bidirectional associations between sleep and cannabis and alcohol (co-)use in daily life.Alcohol, clinical & experimental research · 2024Article
- The Use of Compounds Derived fromInternational journal of molecular sciences · 2024Review
- The Role of Cannabis and The Endocannabinoid System in Sleep Regulation and Cognition: A Review of Human and Animal Studies.Behavioral sleep medicine · 2024Review
- Daily associations with cannabis use and sleep quality in anxious cannabis users.Behavioral sleep medicine · 2024Article
- Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry.Brain and behavior · 2023Article
- Cannabis and sleep disorders: not ready for prime time? A qualitative scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Prospective associations between sleep disturbances and cannabis use among Veterans: A behavioral economic approach.Addictive behaviors · 2022Article
- Changes in striatal dopamine release, sleep, and behavior during spontaneous Δ-9-tetrahydrocannabinol abstinence in male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Effects of rich cannabidiol oil on behavioral disturbances in patients with dementia: A placebo controlled randomized clinical trial.Frontiers in medicine · 2022Article
- Is There a Place for Medicinal Cannabis in Treating Patients with Sleep Disorders? What We Know so Far.Nature and science of sleep · 2022Review
- Are Sweet Dreams Made of These? Understanding the Relationship Between Sleep and Cannabis Use.Cannabis and cannabinoid research · 2021Review
- Marijuana versus evidence-based treatments for sleep and relaxation: A cross-sectional study of use and dose modification following involuntary job loss.Sleep health · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesΔ9-tetrahydrocannabinol (THC) promotes sleep in animals; clinical use of THC is associated with somnolence. Human laboratory studies of oral THC have not shown consistent effects on sleep. We prospectively evaluated self-reported sleep parameters during controlled oral THC administration to research volunteers.
methodsThirteen male chronic daily cannabis smokers (mean ± SD age 24.6± 3.7 years, self-reported smoking frequency of 5.5 ± 5.9 (range 1-24) joint-equivalents daily at study entry) were administered oral THC doses (20 mg) around-the-clock for 7 days (40-120 mg daily) starting the afternoon after admission. The St. Mary's Hospital Sleep Questionnaire was completed every morning. Plasma THC and 11-OH-THC (active metabolite) concentrations were measured in venous blood samples collected every evening. Changes in sleep characteristics over time and associations between sleep characteristics and plasma cannabinoid concentrations were evaluated with repeated measures mixed linear regression.
resultsHigher evening THC and 11-OH-THC concentrations were significantly associated with shorter sleep latency, less difficulty falling asleep, and more daytime sleep the following day. In contrast, the duration of calculated and self-reported nighttime sleep decreased slightly (3.54 and 5.34 minutes per night, respectively) but significantly during the study.
conclusionsThese findings suggest that tolerance to the somnolent effects of THC may have occurred, but results should be considered preliminary due to design limitations. SCIENTIFIC SIGNIFICANCE: Somnolence from oral THC may dissipate with chronic, high-dose use. This has implications for patients who may take chronic oral THC for medicinal purposes, including cannabis dependence treatment. (Am J Addict 2013;22:510-514).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.