Evidence map›Paper›PMID 23952717›Full record

ArticleAIDS research and human retroviruses2013

HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea.

Min Hyung Kim, Je Eun Song, Jin Young Ahn, Yong Chan Kim, Dong Hyun Oh, Heun Choi, Hea Won Ann, Jae Kyoung Kim, Sun Bean Kim, Su Jin Jeong and 5 more

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Min Hyung Kim1 Department of Internal Medicine, Yonsei University College of Medicine , Seoul, Korea.
Je Eun Song
Jin Young Ahn
Yong Chan Kim
Dong Hyun Oh
Heun Choi
Hea Won Ann
Jae Kyoung Kim
Sun Bean Kim
Su Jin Jeong
Nam Su Ku
Sang Hoon Han
Young Goo Song
June Myung Kim
Jun Yong Choi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

Indexed as

MutationAdultAnti-HIV AgentsDrug Resistance, ViralFemaleHIV InfectionsHumansMaleMiddle AgedRepublic of KoreaAnti-HIV Agents

Identifiers

PMID23952717
PMCPMC3848436

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.