Evidence map›Paper›PMID 23951449›Full record

ArticleBoneKEy reports2012

Histomorphometric interpretation of bone biopsies for the evaluation of osteoporosis treatment.

Juliet E Compston

Open access · greenAbstract read
In one paragraph

Article in BoneKEy reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Comparative bone histomorphometry effects of combined denosumab and teriparatide vs monotherapy in postmenopausal women with osteoporosis: a randomized controlled trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Trial
  2. Bone quality changes associated with aging and disease: a review.Annals of the New York Academy of Sciences · 2017
    Review
  3. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Juliet E CompstonDepartment of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital , Cambridge, UK .
Addenbrooke's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone histomorphometry is a valuable tool in the evaluation of bone safety and the mechanism of action of drugs used in the treatment of osteoporosis. Recent studies in patients treated with anti-resorptive agents have highlighted technical issues, in particular, related to the calculation of dynamic indices of bone turnover using fluorochrome labelling. This review addresses the need for standardised approaches for overcoming these problems in order to enable valid comparison of the effects of different interventions on bone remodelling.

Identifiers

PMID23951449
PMCPMC3727704
OpenAlexW2015200653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.