ArticlePloS one2013
The mechanism of antifungal action of a new polyene macrolide antibiotic antifungalmycin 702 from Streptomyces padanus JAU4234 on the rice sheath blight pathogen Rhizoctonia solani.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Pamamycin Disrupts the Cell Envelope and Mitochondrial Potential to InhibitFoods (Basel, Switzerland) · 2026Article
- New Polyene Macrolide Compounds from Mangrove-Derived StrainMarine drugs · 2024Article
- Tolerance and adaptation characteristics of sugar beet (Plant signaling & behavior · 2023Article
- Polyenic Antibiotics and Other Antifungal Compounds Produced by HemolyticInternational journal of molecular sciences · 2022Review
- Exploring the Efficacy of Biocontrol Microbes against the Fungal PathogenFoods (Basel, Switzerland) · 2022Article
- dinF Elicits Nitric Oxide Signaling Induced by Periplanetasin-4 from American Cockroach in Escherichia coli.Current microbiology · 2021Article
- Field Sanitation and Foliar Application ofThe plant pathology journal · 2021Article
- Antifungal Action of Antifungalmycin N2 Against Rhizoctonia solani by Disrupting Cell Membrane and Inhibiting Succinate Dehydrogenase.Current microbiology · 2020Article
- Antagonistic activity and mechanism of an isolated Streptomyces corchorusii stain AUH-1 against phytopathogenic fungi.World journal of microbiology & biotechnology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antifungalmycin 702, a new polyene macrolide antibiotic produced by Streptomycespadanus JAU4234, has a broad antifungal activity and may have potential future agricultural and/or clinical applications. However, the mechanism of antifungal action of antifungalmycin 702 remains unknown. Antifungalmycin 702 strongly inhibited mycelial growth and sclerotia formation/germination of Rhizoctonia solani. When treated with antifungalmycin 702, the hyphae morphology of R. solani became more irregular. The membrane and the cellular organelles were disrupted and there were many vacuoles in the cellular space. The lesion in the plasma membrane was detected through the increase of membrane permeability, lipid peroxidation and leakage of cell constituents. In summary, antifungalmycin 702 may exert its antifungal activity against R. solani by changing the structure of cell membranes and the cytoskeleton and interacting with the organelles.
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