ArticlePloS one2013
Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Review
- Interface-Mediated Neurogenic Signaling: The Impact of Surface Geometry and Chemistry on Neural Cell Behavior for Regenerative and Brain-Machine Interfacing Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Neonatal rat ventricular myocytes interfacing conductive polymers and carbon nanotubes.Cell biology and toxicology · 2023Article
- Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering.Journal of Zhejiang University. Science. B · 2022Article
- Article
- Review
- Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.Scientific data · 2021Article
- Novel carbon film induces precocious calcium oscillation to promote neuronal cell maturation.Scientific reports · 2020Article
- Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering.Biomolecules · 2019Review
- Mucin-like glycopolymer gels in electrosensory tissues generate cues which direct electrolocation in amphibians and neuronal activation in mammals.Neural regeneration research · 2019Article
- Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity.ACS chemical neuroscience · 2019Article
- Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation.ACS applied materials & interfaces · 2017Article
- Physical and electrical characterization of TexasPEG: An electrically conductive neuronal scaffold.Surgical neurology international · 2017Article
- Graphene-Derived Materials Interfacing the Spinal Cord: OutstandingFrontiers in systems neuroscience · 2017Review
- Scale of Carbon Nanomaterials Affects Neural Outgrowth and Adhesion.IEEE transactions on nanobioscience · 2016Article
- Article
- Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective.Frontiers in neuroscience · 2016Review
- Biopersistence of PEGylated Carbon Nanotubes Promotes a Delayed Antioxidant Response after Infusion into the Rat Hippocampus.PloS one · 2015Article
- Carbon-based smart nanomaterials in biomedicine and neuroengineering.Beilstein journal of nanotechnology · 2014Review
- Regenerative nanomedicine: current perspectives and future directions.International journal of nanomedicine · 2014Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, carbon nanotube growth substrates have been used to investigate neurons and neuronal networks formation in vitro when guided by artificial nano-scaled cues. Besides, nanotube-based interfaces are being developed, such as prosthesis for monitoring brain activity. We recently described how carbon nanotube substrates alter the electrophysiological and synaptic responses of hippocampal neurons in culture. This observation highlighted the exceptional ability of this material in interfering with nerve tissue growth. Here we test the hypothesis that carbon nanotube scaffolds promote the development of immature neurons isolated from the neonatal rat spinal cord, and maintained in vitro. To address this issue we performed electrophysiological studies associated to gene expression analysis. Our results indicate that spinal neurons plated on electro-conductive carbon nanotubes show a facilitated development. Spinal neurons anticipate the expression of functional markers of maturation, such as the generation of voltage dependent currents or action potentials. These changes are accompanied by a selective modulation of gene expression, involving neuronal and non-neuronal components. Our microarray experiments suggest that carbon nanotube platforms trigger reparative activities involving microglia, in the absence of reactive gliosis. Hence, future tissue scaffolds blended with conductive nanotubes may be exploited to promote cell differentiation and reparative pathways in neural regeneration strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.