ArticlePloS one2013
Childhood maltreatment is associated with larger left thalamic gray matter volume in adolescents with generalized anxiety disorder.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging.NeuroImage. Clinical · 2019Pooled it
- The common traits of the ACC and PFC in anxiety disorders in the DSM-5: meta-analysis of voxel-based morphometry studies.PloS one · 2014Pooled it
- Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.Human brain mapping · 2024Article
- A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis.BJPsych open · 2024Review
- Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study.BMC psychiatry · 2024Article
- Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood.Development and psychopathology · 2022Article
- Neighborhood Disadvantage Associated With Blunted Amygdala Reactivity to Predictable and Unpredictable Threat in a Community Sample of Youth.Biological psychiatry global open science · 2022Article
- Brain Iron and Mental Health Symptoms in Youth with and without Prenatal Alcohol Exposure.Nutrients · 2022Article
- Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment.European child & adolescent psychiatry · 2022Article
- Gray Matter Volume of Thalamic Nuclei in Traumatized North Korean Refugees.Frontiers in psychiatry · 2022Article
- A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma.Frontiers in human neuroscience · 2022Article
- Identifying profiles of brain structure and associations with current and future psychopathology in youth.Developmental cognitive neuroscience · 2021Article
- Longitudinal association between parental-to-child-Maltreatment and self-reported Generalized Anxiety Disorder symptoms in Pakistani Adolescents.Child and adolescent psychiatry and mental health · 2021Article
- The Role of the Thalamus in Post-Traumatic Stress Disorder.International journal of molecular sciences · 2021Review
- Default Mode Network Alterations Induced by Childhood Trauma Correlate With Emotional Function and SLC6A4 Expression.Frontiers in psychiatry · 2021Article
- The Association of Adverse Childhood Experiences and Resilience With Health Outcomes in Adolescents: An Observational Study.Global pediatric health · 2021Article
- Peer victimization and its impact on adolescent brain development and psychopathology.Molecular psychiatry · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeneralized anxiety disorder (GAD) is a common anxiety disorder that usually begins in adolescence. Childhood maltreatment is highly prevalent and increases the possibility for developing a variety of mental disorders including anxiety disorders. An earlier age at onset of GAD is significantly related to maltreatment in childhood. Exploring the underpinnings of the relationship between childhood maltreatment and adolescent onset GAD would be helpful in identifying the potential risk markers of this condition.
methodsTwenty-six adolescents with GAD and 25 healthy controls participated in this study. A childhood trauma questionnaire (CTQ) was introduced to assess childhood maltreatment. All subjects underwent high-resolution structural magnetic resonance scans. Voxel-based morphometry (VBM) was used to investigate gray matter alterations.
resultsSignificantly larger gray matter volumes of the right putamen were observed in GAD patients compared to healthy controls. In addition, a significant diagnosis-by-maltreatment interaction effect for the left thalamic gray matter volume was revealed, as shown by larger volumes of the left thalamic gray matter in GAD patients with childhood maltreatment compared with GAD patients without childhood maltreatment as well as with healthy controls with/without childhood maltreatment. A significant positive association between childhood maltreatment and left thalamic gray matter volume was only seen in GAD patients.
conclusionsThese findings revealed an increased volume in the subcortical regions in adolescent GAD, and the alterations in the left thalamus might be involved in the association between childhood maltreatment and the occurrence of GAD.
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